テトラヒドロフランアセトゲニン類の構造解析-プレカーサーイオンスキャン法の適用-
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概要
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Tetrahydrofuranic (annonaceous) acetogenins are a new class of bioactive natural products isolated from several genera of Annonaceae plants. We have isolated nearly thirty these acetogenins from the seeds of <I>Annona squamosa</I> and <I>A</I>. <I>reticulata</I> Their structures have been elucidated by the application of precursor-ion scanning method in mass spectrometry. Thus, these compounds were converted into lactam derivatives on treatment with amines such as <I>N, N</I>-dimethylethylenediamine. Precursor-ion scanning spectra of the derivatives from a specific fragment ion due to C-N bond cleavage were measured. This newly developed method allowed to establish unambiguously the planar structures of tetrahydrofuranic acetogenins. Biological activity and stereochemical aspects of annonaceous acetogenins are also reviewed.
- 社団法人 有機合成化学協会の論文
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