活性型ビタミンD
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概要
- 論文の詳細を見る
Since the discovery of 1, 25-dihydroxyvitamin D<SUB>3</SUB>, our knowledge of the metabolic activation and the mode of action of vitamin D has expanded dramatically during the past 15 years. About 40 kinds of the metabolites were isolated. Many analogs of those metabolites have been synthesized in order to obtain higher activity and to separate various biological activities. Recently, a specific receptor for 1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB> was demonstrated in many tissues and tumor cells, and the induction of cell differentiation of myeloid leukemia cells by 1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB> was reported. Vitamin D analogs have been tested for the activity. Usually parallel activities were observed for the calcium regulation effect and cell differentiation. Synthetic analogs, 24-homo-1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB>, 26, 27-diethyl-1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB>, and 24, 24-F<SUB>2</SUB>-24-homo-1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB> were found to be 10 fold more potent than 1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB> in inducing differentiation of HL-60 cells, but almost inactive in calcium regulation. Thus, the separation of two major actions of 1, 25- (OH) <SUB>2</SUB>D<SUB>3</SUB> could be achieved.
- 社団法人 有機合成化学協会の論文
著者
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池川 信夫
新潟薬科大学
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池川 信夫
いわき明星大学理工学部
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池川 信夫
いわき明星大学
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藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
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藤本 善徳
東京工業大学大学院理工学研究科
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- 活性型ビタミンD : 最近の新展開