Synthesis of 3β, 6α-Dihydroxycholesta-9(11), 17(20), 24-trien-23-one, the Aglycone of Acrosome Reaction-Inducing Steroidal Saponin Co-ARIS II
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概要
- 論文の詳細を見る
3β, 6α-Dihydroxycholesta-9(11), 17(20), 24-trien-23-one (2), the aglycone of acrosome reaction-inducing steroidal saponin Co-ARIS II (1), was synthesized from asterone diacetate (3) in 8 steps. The side chain was constructed by the coupling reaction of the allyl chloride (8) with the dithiane anion (9). Evidence for 17(20)-E stereochemistry of 2 was obtained by nuclear Overhauser effect (NOE) experiments in the proton nuclear magnetic resonance (^1H-NMR) spectrum. Comparison of the ^1H- and ^<13>C-NMR data of 2 with those of 1 confirmed the structure assignment of the latter compound.
- 社団法人日本薬学会の論文
- 1988-08-25
著者
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池川 信夫
新潟薬科大学
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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藤本 善徳
Department of Chemistry, Tokyo Institute of Technology
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藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
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柿沼 勝己
Department of Chemistry, Tokyo Institute of Technology
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山田 岳俊
Department of Chemistry, Tokyo Institute of Technology
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中村 和美
Department Of Chemistry Tokyo Institute Of Technology
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柿沼 勝己
Department Of Chemistry Tokyo Institute Of Technology
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山田 岳俊
Department Of Chemistry Tokyo Institute Of Technology
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