Studies on Steroids. LXIII. Synthesis of Cholesterol Analogs with a Modified Side Chain
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概要
- 論文の詳細を見る
The Li_2CuCl_4-catalyzed Grignard reaction of the p-toluenesulfonates of 3β-tetrahydropyranyloxybisnorchol-5-en-22-ol (9) and 3β-tetrahydropyranyloxychol-5-en-24-ol (3) afforded several cholesterol analogs with a modified side chain (10). The reaction of 9 with 3-methyl-2-butenylmagnesium chloride gave a mixture of desmosterol (11) and its allylic isomer (12) in a ratio of 2 : 1. 25-Methylcholesterol (7) was prepared from the cholanal derivative (5) by reaction with t-butylmagnesium bromide followed by deoxygenation of the resulting 24-carbinol 6.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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池川 信夫
Laboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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今村 信孝
北里研
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Duque Carmenza
Laboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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今村 信孝
Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology
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森崎 益雄
Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology
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柴田 真弓
Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology
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柴田 真弓
Laboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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