Preparation of Desmosterol from Fucosterol

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概要

• 論文の詳細を見る

• Desmosteryl acetate, a useful key intermediate for synthesis of the metabolites of vitamin D_3,was synthesized from fucosterol by two routes ; (1) 24,28-epoxyfucosteryl acetate was treated with solid acids such as zeolite, silica-alumina and alumina-boria to give desmosteryl acetate in a yield of 16%-40%, (2) dehydration of 24-hydroxycholesteryl acetate, which was obtained by ozonolysis of fucosteryl acetate followed by reduction with sodium borohydride, with P_2O_5 in benzene afforded desmosteryl acetate in a yield of 85%.

• 公益社団法人日本薬学会の論文
• 1976-08-25

著者

• 池川 信夫

  Laboratory Of Chemistry For Natural Products Tokyo Institute Of Technology

• 池川 信夫

  東京工大 理

• 石本 祐男

  Teijin Institute For Biomedical Research

• 竹下 徹

  Teijin Institute Of Biomedical Research

関連論文

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• 7.活性型ビタミンD_3(1α-OH-D_3)の安全性研究 : 急性及び亜急性毒性試験(脂溶性ビタミン総合研究委員会 : 第154回会議研究発表要旨)
• Synthesis of (23R)-Calcidiol Lactone (25-Hydroxyvitamin D_3 26,23-Lactone)
• Identification of the Aglycon Part of Vineomycin A_1 with Aquayamycin
• Studies on Steroids. LXIII. Synthesis of Cholesterol Analogs with a Modified Side Chain
• Carbon-13 Nuclear Magnetic Resonance of 24-Substituted Steroids
• Synthesis of Active Forms of Vitamin D. VIII. Synthesis of [24R] -and [24S] -1α, 24,25-Trihydroxyvitamin D_3
• Synthesis of Demethylgorgosterol and Its Stereoisomers
• Studies on Steroids. XLV. Synthesis of the Four Stereoisomers of 20,22-Dihydroxycholesterol
• Hydrogenolysis of Allylic Alcohols with Mixed Hydride Reagent of Lithium Aluminum Hydride-Titanium Tetrachloride
• Withanolideの合成と生理活性
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• Studies on Steroids. LI. Stereoselective Introduction of 22- and 24-Hydroxyl Function in the Steroidal Side Chain
• Stereochemistry of Electrophilic Reactions at the Steroidal C-22 Double Bond
• Synthesis of (22R)-and (22S)-22,25-Dihydroxyvitamin D_3 and Determination of Their Biological Activity
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• Preparation of Desmosterol from Fucosterol
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• Synthesis of Active Forms of Vitamin D. V. A Practical Route to 1α, 25-Dihydroxycholesterol
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• Withanolideの合成と生理活性
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• Synthesis of Active Forms of Vitamin D. X. Synthesis of 1α-Hydroxyvitamin D_3
• Synthesis of Active Forms of Vitamin D. III. Synthesis of 1α, 25-Dihydroxycholesterol
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• Studies on Steroids. XXXIX. Sterol Profiles of Red Algae. (2)
• Studies on Steroids. XXXVIII. A New Preparation of 1α-Hydroxycholesterol
• 2.活性型ビタミンD_3群の合成について(紹介講演)(脂溶性ビタミン総合研究委員会 : 第155回会議研究発表要旨)
• Synthesis of Active Forms of Vitamin D. II. Synthesis of 1α-Hydroxycholesterol

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