75 セトミマイシンの構造と生合成

概要

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The Structure of an antibacterial and antitumor antibiotic Setomimycin produced by Streptomyces pseudovenezuelae AM-2947, was determined to be a unique substituted 9,9'-bianthryl (1), first to be reported from Antinomycetes, by means of the various new ^<13>C-nmr techniques including ^<13>C-{^1H}-selective decoupling, ^<13>C-{^1H}-selective population transfer and ^<13>C-{^1H}-NOE experiments. Biosynthetic studies of the antibiotic were also carried out by labeling either with [1-^<13>C]-or [1,2-^<13>C_2]-sodium acetates. The labeling pattern was determined by the ^<13>C-^<13>C coupling constants with the aid of ^<13>C-{^<13>C}-homonuclear decoupling experiments, which allowed to verify the assigned structure of setomimycin and to elucidate that the antibiotic is derived from two nonaketide metabolites via decarboxylation at the terminals.
天然有機化合物討論会の論文
1980-09-10