Cage Effect for the Photochemical Formation of the Ten-Membered Lactam from N-Chloroacetyl-3-methoxyphenethylamine
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概要
- 論文の詳細を見る
Photocyclization of N-chloroacetyl-3-methoxyphenethylamine (I) in water gave 7- and 9-methoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-2-ones (V and VI), whereas in organic solvents the main products changed to N-acetyl-3-methoxyphenethylamine (XVII) and 2-oxa-6-azabicyclo [7,3,1] trideca-1 (13), 9,11-trien-5-one (XIII). Quantum yield for the formation of V and VI is clearly dependent on the polarity of solvent indicating that the formation of V and VI involves an ionic process. In organic solvents, viscous media favor the formation of XIII. Viscosity dependence in some alcohols is probably an indication of a novel cage reaction operative in the formation of the lactam XIII.
- 公益社団法人日本薬学会の論文
- 1975-05-25
著者
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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米光 宰
北海道大学薬学部
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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奥野 洋明
Faculty of Pharmaceutical Sciences, Hokkaido University
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奥野 洋明
Faculty Of Pharmaceutical Sciences Hokkaido University
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米光 宰
北大 薬
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