Preliminary Studies on the Stereochemistry of Emetine. I. Mercuric Acetate Dehydrogenation of (-)-2'-Acylemetines

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概要

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• Mercuric acetate dehydrogenation of (-)-2'-acylemetines, which have the same configuration as (-)-emetine, was found to afford 5,11b-dehydro-2'-acylemetines. In preliminary experiments, it was shown that 1-alkyl-1,2,3,4-tetrahydroisoquinoline derivatives are dehydrogenated with the same reagent to afford 3,4-dihydro compounds, but the corresponding 2-acyl compounds resisted similar dehydrogenation. These results seem to strongly support Openshaw's view about the structure of tetradehydroemetine.

• 公益社団法人日本薬学会の論文
• 1960-03-25

著者

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 伴 義雄

  School Of Pharmaceutical Science Toho University

• 伴 義雄

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 寺島 正直

  Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University

• 米光 宰

  Pharmaceutical Institute, School of Medicine, University of Hokkaido

• 寺島 正直

  Pharmaceutical Institute Medical Faculty University Of Tokyo

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