Stereoselective Total Synthesis of 16-Membered Macrolide Aglycons, Leuconolides and Maridonolides. Macrocylic Stereocontrol Based on Conformational Analysis of the 16-Membered Macrolide Ring
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概要
- 論文の詳細を見る
Sixteen-membered macrolide aglycons with different oxidation levels, leuconolide A_1 (3a), leuconolide A_3 (3b), midecanolide A_1 (3c), maridonolide II (4a), and maridonolide I (4b), were synthesized from two carbonolide type compounds (1,2) by stereoselective reduction and epoxidation on the 16-membered ring system. The conformational analysis of macrolide rings based on nuclear magnetic resonance measurements and MMP2 calculations is also discussed in relation to the stereoselective synthesis of the five macrolide aglycons (3a-4b).
- 公益社団法人日本薬学会の論文
- 1991-11-25
著者
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中島 範行
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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米光 宰
岡山理大理
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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中島 範行
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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松嶋 知広
Faculty of Pharmaceutical Sciences, Hokkaido University
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後藤 仁志
Department of Knowledge-Based Information Engineering, Toyohashi University of Technology
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大澤 映二
Department of Knowledge-Based Information Engineering, Toyohashi University of Technology
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大澤 映二
豊橋技科大
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松嶋 知広
Faculty Of Pharmaceutical Sciences Hokkaido University
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後藤 仁志
豊橋技術科学大学大学院
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