マクロリドの合成 : 高い選択性と効率をもった易しい合成法を確立するために

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概要

• 論文の詳細を見る

• In order to establish a simple common methodology for the highly stereoselective and efficient synthesis of macrolide aglycones, 12-membered ring methynolide and 16-membered ring tylonolide were synthesized from D-glucose via the synthesis of respective fragments followed by their coupling (esterification by the Yamaguchi method) and cyclization by the Wittig-Horner reaction under Nicolaous conditions. This method was extended to the synthesis of 14-membered ring pikronolide and, together with conformational control of macrolide rings, to some typical 16-membered ring aglycones such as carbonolides, leuconolides, maridonolides, etc. A new synthesis of erythronolide A via an extremely efficient macrolactonization by virtue of conformational control and super activation of the seco-acid is also described.

• 社団法人 有機合成化学協会の論文

著者

• 米光 宰

  北海道大学薬学部

• 米光 宰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 彦田 匡毅

  北大薬

• 米光 宰

  北海道大学

• 中島 範行

  北海道大学薬学部

• 彦田 匡毅

  北海道大学薬学部

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