Photocyclization of N-Chloroacetyl-3-methoxyphenethylamine and N-Chloroacetyl-3,5-dimethoxyphenethylamine.

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概要

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• On irradiation of N-chloroacetyl derivatives of 3-methoxyphenethylamine (VII) and 3,5-dimethoxyphenethylamine (XV) in 10% aqueous ethanol, 1,2,4,5-tetrahydro-3H-3-benzazepin-2-ones (VIII, IX, and XVI) were synthesized in good yield, whereas in ethanol novel ten-membered lactams (XIII and XVII) were main products. The photo-reaction of N-chloroacetylphenethylamine (XXI) in the presence or absence of veratrol (XXV) gave the intermolecular reaction product (XXVI) or the radical reaction products (XXII and XXIV), which may support the proposed dualistic mechanism.

• 公益社団法人日本薬学会の論文
• 1972-06-25

著者

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 米光 宰

  北海道大学薬学部

• 米光 宰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 奥野 洋明

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 逸見 恵次

  Faculty of Pharmaceutical Sciences Hokkaido University

• 奥野 洋明

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 米光 宰

  北大 薬

• 逸見 恵次

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

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