Studies on Structure-Activity Relationships of FK-156,an Immunostimulating Peptide, and Related Compounds. II. Synthesis of N^2-(γ-D-Glutamyl)-2 (L), 2' (D)-diaminopimelic Acid as the Minimal Essential Structure of FK-156
スポンサーリンク
概要
- 論文の詳細を見る
Five partial structures, 3-7,of FK-156 (1), an immunostimulating acyl peptide, have been prepared. The compounds were evaluated for biological activities, and it was found that N^2-(γ-D-glutamyl)-2 (L), 2' (D)-diaminopimelic acid (3) represents the minimal active structure unit essential for the immunostimulating property of FK-156 (1). Its caprylyl derivative 8 and stearoyl derivative 9 were found to be capable of increasing resistance to bacterial infection as efficiently as 1. Moreover, compound 9 showed a potent tumor-suppressive activity lacking in 1.
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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岡田 達
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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武野 秀一
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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武野 秀一
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Hemmi K
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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逸見 恵次
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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北浦 良彦
(Present address)Pfizer Central Research
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中口 修
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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北浦 良彦
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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余西 敏
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Hashimoto M
Exploratory Research Laboratories Fujisawa Phamaceutical Co. Ltd. :(present Address)tsukuba Research
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余西 敏
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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中口 修
藤沢薬品工業
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