Synthesis and Aldose Reductase-Inhibitory Activities of Structural Analogues of WF-3681,a Novel Aldose Reductase Inhibitor

スポンサーリンク

概要

• 論文の詳細を見る

• Various analogues of WF-3681 (1a), a novel aldose reductase inhibitor, were synthesized and examined for aldose reductase-inhibitory activity. It was found that the carboxylic acid function is necessary and the side-chain length is important for the activity. Furthermore, the lipophilicities of the benzene ring and the enol ether group are significant for increasing the activity.

• 公益社団法人日本薬学会の論文
• 1988-04-25

著者

• 鈴木 康隆

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 奥 照夫

  Exploratory reserch Laboratries, Fujisawa Pharmaceutical Co., Ltd.

• 奥 照夫

  藤沢薬品探研

• 橋本 真志

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 伊藤 義邦

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 西川 元章

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 沢田 弘造

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 西川 元章

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 奥 照夫

  Exploratory Reserch Laboratries Fujisawa Pharmaceutical Co. Ltd.

• 橋本 真志

  Exploratory Research Laboratories Fujisativa Pharmaceutical Co. Ltd.

• 並木 隆之

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 馬場 幸久

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 北浦 良彦

  (Present address)Pfizer Central Research

• 伊藤 義邦

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 並木 隆之

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 馬場 幸久

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

関連論文

• Odorous Metabolites of Actinomyces Biwako-C and -D Strain isolated from the Bottom Deposits of Lake Biwa. Identification of Geosmin, 2-Methylisoborneol, and Furfural
• Synthesis of Kifunensine, an Immunomodulating Substrate Isolated from a Microbial Source
• 22 Kifunensineおよび8-epi-kifunensineの合成(口頭発表の部)
• 83(P69) 新規微小管作用物質WS9885B(ポスター発表の部)
• A New Metabolite from Pseudomonas pyrrolnitrica
• 2-(2-Heptenyl)-3-methyl-4-quinolinol from a Pseudomonas
• Oxypryrrolnitrin : A Metabolite of Pseudomonas
• STRUCTURE AND SYNTHESIS OF FK409,A NOVEL VASODILATOR ISOLATED FROM STREPTOMYCES AS A SEMI-ARTIFICIAL FERMENTATION PRODUCT
• Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. III. Pharmacological Studies of FR-900452 in Animal Models
• Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. I. : Bisdethiobis(methylthio)gliotoxin and Its Derivatives
• 13 Amauroascus属菌の生産する降圧作用を有するアルカロイド WF6237の構造と合成
• STRUCTURE AND SYNTHESIS OF WB-3559 A, B, C AND D, NEW FIBRINOLYTIC AGENTS ISOLATED FROM FLAVOBACTERIUM sp.
• A Cytolytic Substance, Monopodialysin obtained from a Streptomyces. I. Isolation and Characterization of Monopodialysin produced by Streptomyces aureomonopodiales
• Synthesis and Aldose Reductase-Inhibitory Activities of Structural Analogues of WF-3681,a Novel Aldose Reductase Inhibitor
• Enantioselective Synthesis of Monocyclic β-Lactams Related to Nocardicins via a [2+2] Cycloaddition Reaction(Organic,Chemical)
• Preparation of 3-Aminonocardicinic Acid and Its Acyl Derivatives(Organic,Chemical)
• AN EFFICIENT SYNTHESIS OF WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR, AND ITS RELATED COMPOUNDS(Communications to the Editor)
• 35 3-アザセファロスポリンの合成
• 43 ペニシリンよりModified β-lactam Antibioticsへの変換
• Synthesis of Some Polyhydroxylated Pyrrolidine Derivatives(Organic,Chemical)
• SYNTHESIS AND ADJUVANT ACTIVITY OF FK-156 ANALOGUES : ACYL DERIVATIVES OF N-[N^2-(L-ALANYL-γ-D-GLUTAMYL)-2 (L), 2'(D)-DIAMINO-1-PIMELOYL] GLYCINE
• Studies on Structure-Activity Relationships of FK-156,an Immunostimulating Peptide, and Related Compounds. II. Synthesis of N^2-(γ-D-Glutamyl)-2 (L), 2' (D)-diaminopimelic Acid as the Minimal Essential Structure of FK-156
• Studies on Structure-Activity Relationships of FK-156,an Immunostimulating Peptide, and Related Compounds. I. Synthesis of Stereoisomeric Analogues of FK-156
• SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF FK-156 ANALOGUES : FATTY ACID DERIVATIVES OF N-[N^α-(γ-D-GLUTAMYL)-L-LYSYL]-D-ALANINE
• Studies on Phosphonic Acid Antibiotics. IV. Synthesis and Antibacterial Activity of Analogs of 3-(N-Acetyl-N-hydroxyamino)-propylphosphonic Acid (FR-900098)
• 76 免疫増強作用を有する微生物代謝産物Gludapcin(FK-156)の合成
• Studies on Phosphonic Acid Antibiotics. III. Structure and Synthesis of 3-(N-Acetyl-N-hydroxyamino) propylphosphonic Acid (FR-900098) and 3-(N-Acetyl-N-hydroxyamino)-2 (R)-hydroxypropyl-phosphonic Acid (FR-33289)
• Lithium Aluminum Hydride Partially Decomposed with (-)-N-Methylephedrine and 2-Alkylaminopyridine : An Improved Chiral Hydride Useful for the Practical Asymmetric Reduction of Achiral Cyclic Ketones
• Synthesis of Trilobine, Isotrilobine, and Obaberine
• Synthesis 8-epi-Kifunensine
• SYNTHESIS OF 8-EPI-KIFUNENSINE
• 最近のβ-ラクタム抗生物質の化学
• Hypocholesterolemic Alkaloids of Lentinus edodes (BERK.) SING. IV. Synthesis of Three Stereoisomers of Eritadenine
• Hypocholesterolemic Alkaloids of Lentinus edodes (BERK.) SING. III. Preparation of Analogous Compounds related to Eritadenine

もっと見る 閉じる

スポンサーリンク