Hypocholesterolemic Alkaloids of Lentinus edodes (BERK.) SING. III. Preparation of Analogous Compounds related to Eritadenine
スポンサーリンク
概要
- 論文の詳細を見る
Various compounds related to the hypocholesterolemic alkaloid eritadenine (I) were synthesized for the evaluation of structure-activity relationships in this series. 6-Sub-stituted purine analogs were prepared by reacting the 6-chloro-purine intermediate (II) with the corresponding nucleophilic reagents. 2,6-Di-substituted purine derivatives were prepared by utilizing a route involving an imidazole ring closure step, starting from the appropriately substituted pyrimidine precursors and the amino-acid (VI). The preparation of 6,8-di-substituted purine analogs was achieved by cyclization of the 5-amino-pyrimidine intermediate (XXIX) derived for the synthesis of I.
- 公益社団法人日本薬学会の論文
- 1972-06-25
著者
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紙谷 孝
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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橋本 真志
Research Laboratories, Fujisawa pharmaceutical Co., Ltd.
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関 英男
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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紙谷 孝
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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橋本 真志
Exploratory Research Laboratories Fujisativa Pharmaceutical Co. Ltd.
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斎藤 能久
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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斎藤 能久
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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紙谷 孝
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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