Studies on Phosphonic Acid Antibiotics. IV. Synthesis and Antibacterial Activity of Analogs of 3-(N-Acetyl-N-hydroxyamino)-propylphosphonic Acid (FR-900098)

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概要

• 論文の詳細を見る

• The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098,Ia) and an analysis of their structure-activity relationship are described. Among them, compounds Ib (FR-31564) and XIIb (FR-32863) have recently been found to be produced naturally by Streptomyces lavendulae. The antibacterial activity of Ib against Pseudomonas species is especially significant.

• 公益社団法人日本薬学会の論文
• 1982-01-25

著者

• 紙谷 孝

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 橋本 真志

  Research Laboratories, Fujisawa pharmaceutical Co., Ltd.

• 武野 秀一

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 逸見 恵次

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 紙谷 孝

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 橋本 真志

  Exploratory Research Laboratories Fujisativa Pharmaceutical Co. Ltd.

• 逸見 恵次

  Research Laboratories, Fuiisawa Pharmaceutical Co., Ltd.

• 武野 秀一

  Research Laboratories, Fuiisawa Pharmaceutical Co., Ltd.

• 紙谷 孝

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

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