Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. I. : Bisdethiobis(methylthio)gliotoxin and Its Derivatives
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概要
- 論文の詳細を見る
A platelet activating factor (PAF) antagonist, designated as FR-49175,was isolated from fermentation products of Penicillium terlikowskii and identified as bisdethiobis(methylthio)-gliotoxin (1). The IC_<50> value of this compound for PAF-induced rabbit platelet aggregation was 8.4 μM.Some derivatives of bisdethiobis(methylthio)gliotoxin (1) were synthesized and their inhibitory activities of PAF-induced platelet aggregation were examined. Among these compounds, 5a, 6-anhydrobisdethio-3,10a-bis(methylthio)gliotoxin (8) showed the most potent PAF inhibitory activity (IC_<50>; 4.4 μM).
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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青木 初夫
藤沢薬品工業(株)
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青木 初夫
藤沢薬品工業株式会社
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岡本 正則
藤沢薬品工業(株)探索研究所
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吉田 啓造
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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内田 逸郎
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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岡本 正則
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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向阪 正信
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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吉田 啓造
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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西川 元章
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
-
青木 初夫
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
-
向坂 正信
藤沢薬品工業株式会社
-
青木 初夫
藤沢薬品工業(株)探索研究所
-
吉田 啓造
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
西川 元章
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
内田 逸郎
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
向阪 正信
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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