Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. II. : Pharmacological Studies of FR-49175 in Animal Models
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概要
- 論文の詳細を見る
Platelet activating factor (PAF) antagonistic action of FR-49175 was studied using in vivo models designated as PAF-induced bronchconstriction, hypotension and vascular permeability increase. This compound (0.1 mg/kg, i.v.) significantly inhibited PAF-induced bronchoconstriction in guinea-pigs. However, it did not prevent PAF-induced hypotension in rats or vascular permeability increase in mice. Furthermore, the effect of this compound against a systemic anaphylaxis model in guinea-pigs was examined, but it did not show any inhibition of antigen-induced mortality at the dose of 10 mg/kg, i.v.
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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青木 初夫
藤沢薬品工業(株)
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青木 初夫
藤沢薬品工業株式会社
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岡本 正則
藤沢薬品工業(株)探索研究所
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吉田 啓造
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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内田 逸郎
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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岡本 正則
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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向阪 正信
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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吉田 啓造
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
-
青木 初夫
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
-
向坂 正信
藤沢薬品工業株式会社
-
青木 初夫
藤沢薬品工業(株)探索研究所
-
吉田 啓造
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
内田 逸郎
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
向阪 正信
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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