41 14員環マクロリドのセコ酸誘導体の立体配座計算とマクロラクトン化(口頭発表の部)

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概要

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• The macrolactonization of seco acid derivatives is a key step of the total synthesis of macrolide antibiotics such as erythronolide A(3), lankanolide (4) and oleandonolide (5) and the efficiency of lactonization depends upon the conformation of the seco acid derivatives. Therefore, in order to design the rational plan for the total synthesis of macrolide antibiotics, the conformational analysis of their seco acids is very important. We calculated stable comformations of the known seco acids 7 and 9 using the MM2-CONFLEX31 method recently developed by E. Osawa et al., and discussed the correlation of their reactivity to give lactone and their stable conformation calculated. The unknown seco acids 13, 14, 17 and 18 were also calculated to analyze their stable conformers and the prediction of their lactonization were discussed.

• 天然有機化合物討論会の論文
• 1991-09-07

著者

• 米光 宰

  岡山理大理

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 米光 宰

  北大薬

• 米光 宰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 彦田 匡毅

  北大薬

• 浜田 辰夫

  北大薬

• 大澤 映二

  豊橋技科大工

• 後藤 仁志

  北大理

• 大澤 映二

  豊橋技科大

• 後藤 仁志

  豊橋技術科学大学大学院

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