Highly Stereocontrolled Total Synthesis of the Polyether Antibiotic Salinomycin. I. Synthesis of the Left (C1-C9) and Middle (C10-C17) Segments from D-Glucose
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概要
- 論文の詳細を見る
The required left (C1-C9) segment, (R)-2-[(2R, 5S, 6R)-6-[(R)-1-formylethyl]-5-methyltetrahydropyran-2-yl]butanoic acid, for a total synthesis of salinomycin was highly stereoselectively synthesized from D-glucose via a chelation-controlled Grignard reaction and a decarbonylation with Wilkinson's catalyst as important steps. The stereoselective synthesis of the middle (C10-C17) segment, (2R, 4S, 5S, 6R)-6-ethyl-2,4-dimethyl-7-oxononan-5-olide, starting from D-glucose is also described.
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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及川 裕二
Faculty Of Pharmaceutical Sciences Hokkaido University
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米光 宰
岡山理大理
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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及川 裕二
北大薬
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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堀田 清
Faculty of Pharmaceutical Sciences, Hokkaido University
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堀田 清
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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