Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 7. Synthesis of Two C27-C36 Units via Construction of the F Ring and Completely Stereoselective C-Glycosylation Using Mixed Lewis Acids
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概要
- 論文の詳細を見る
Two C27-C36 units of halichondrin B were synthesized starting from a C31-C34 alcohol, which was easily available from dimethyl L-tartrate, via construction of the F ring, methylation at the C31 position and C-glycosylation. These crucial reactions proceeded completely stereoselectively, and in particular the stereoselective C-glycosylation with allyltrimethylsilane took place only in the presence of both of two Lewis acids, boron trifluoride etherate and trimethylsilyl triflate.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
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Yonemitsu O
Hokkaido Univ. Sapporo Jpn
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HORITA Kiyoshi
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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堀田 清
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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NAGASAWA Masaaki
Faculty of Pharmaceutical Sciences, Hokkaido University
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SAKURAI Youji
Faculty of Pharmaceutical Sciences, Hokkaido University
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YONEMITSU Osamu
Department of Chemistry, Okayama University of Science
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Sakurai Y
Faculty Of Pharmaceutical Sciences Hokkaido University
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Horita Kiyoshi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Yonemitsu Osamu
Departmen Of Chemistry Okayama University Of Science
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Nagasawa M
Faculty Of Pharmaceutical Sciences Hokkaido University
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