Synthetic Studies on Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 9. Synthesis of the C16-C36 Unit via Stereoselective Construction of the D and E Rings
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概要
- 論文の詳細を見る
The C16-C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16-C26 esters with the previously synthesized C27-C36 aldehyde followed by E ring construction. The C16-C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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Yonemitsu O
Hokkaido Univ. Sapporo Jpn
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HORITA Kiyoshi
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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堀田 清
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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NAGASAWA Masaaki
Faculty of Pharmaceutical Sciences, Hokkaido University
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SAKURAI Youji
Faculty of Pharmaceutical Sciences, Hokkaido University
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YONEMITSU Osamu
Department of Chemistry, Okayama University of Science
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Sakurai Y
Faculty Of Pharmaceutical Sciences Hokkaido University
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Horita Kiyoshi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Yonemitsu Osamu
Departmen Of Chemistry Okayama University Of Science
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Nagasawa M
Faculty Of Pharmaceutical Sciences Hokkaido University
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