Synthetic Studies of an 18-Membered Antitumor Macrolide, Tedanolide. 6. Synthesis of a Key Intermediate via a Highly Efficient Macrolactonization of Computer-Aid Designed Seco-Acid
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概要
- 論文の詳細を見る
A stereoselective synthesis is described of the 18-membered lactone (2) via an efficient macrolactonization of the conformation-controlled seco-acid (3); this was designed with the aid of molecular mechanics (MM)-calculation and synthesized by coupling between the C1-C12 (4) and C13-C23 (5) fragments.
- 公益社団法人日本薬学会の論文
- 2000-06-01
著者
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Yonemitsu O
Hokkaido Univ. Sapporo Jpn
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Nakajima Noriyuki
Biotechno-logy Research Center, Toyama Prefectural University
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YONEMITSU Osamu
Department of Chemistry, Okayama University of Science
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Nakajima Noriyuki
Biotechnology Center Toyama Prefectural University
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Nakajima Noriyuki
Biotechno-logy Research Center Toyama Prefectural University
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Zheng B‐z
Okayama Univ. Sci. Okayama Jpn
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Zheng Bao-zhong
Department Of Chemistry Okayama University Of Science
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Matsushima Tomohiro
Faculty Of Pharmaceutical Sciences Hokkaido University
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Yonemitsu Osamu
Departmen Of Chemistry Okayama University Of Science
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Nakajima N
Biotechno-logy Research Center Toyama Prefectural University
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