Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 6. Synthesis of the C1-C15 Unit via Stereoselective Construction of the B and A Rings by Kinetically and Thermodynamically Controlled Michael Reactions wi
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概要
- 論文の詳細を見る
The C1-C15 unit of halichondrin B was synthesized starting from D-glucose via stereoselective construction of the B and A rings, which have 2,6-trans- and 2,6-cis-disubstituted tetrahydropyran rings, respectively. With the aid of MM2 calculations kinetically and thermodynamically controlled Michael reactions were successfully applied for the construction of the B and A rings, respectively.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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HORITA Kiyoshi
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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YONEMITSU Osamu
Department of Chemistry, Okayama University of Science
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Horita Kiyoshi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Yamazaki Tatsuya
Department of Instrumentation Engineering, Faculty of Science and Technology, Keio University
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Yonemitsu Osamu
Department Of Chemistry Okayama University Of Science
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Yonemitsu Osamu
Departmen Of Chemistry Okayama University Of Science
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HACHIYA Shun-ichiro
Faculty of Pharmaceutical Sciences, Hokkaido University
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NAITOU Tae
Department of Chemistry, Okayama University of Science
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Naitou Tae
Department Of Chemistry Okayama University Of Science
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Uenishi J
Department Of Chemistry Okayama University Of Science
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Hachiya S
Faculty Of Pharmaceutical Sciences Hokkaido University
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Yamazaki Tatsuya
Department Of Chemistry Okayama University Of Science
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Yamazaki Tatsuya
Department Of Applied Chemistry Graduate School Of Engineering Tohoku University
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