Highly Stereocontrolled Total Synthesis of the Polyether Antibiotic Salinomycin. III. Total Synthesis of Salinomycin via Coupling of C1-C9,C10-C17,and C18-C30 Segments
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概要
- 論文の詳細を見る
The polyether antibiotic salinomycin was synthesized via coupling between the C10-C17 aldehyde, (2R, 4S, 5S, 6S, 7R)-6-ethyl-5,7-isopropylidenedioxy-2,4-dimethylnonanal, and C18-C30 acetylenes, for example, (3R, 4R, 7S)-4,7-bis(tert-butyldimethylsilyloxy)-7-[(2R, 5R, 6S)-5-ethyl-5-(4-methoxybenzyloxy)-6-methyltetra-hydropyran-2-yl]-3-(4-methoxybenzyloxy)oct-1-yne, followed by the aldol condensation with the C1-C9 segment, (R)-2-[(2R, 5S, 6R)-6-[(R)-1-formylethyl]-5-methyltetrahydropyran-2-yl]butanoic acid. In this total synthesis, protection of hydroxy groups with the 4-methoxybenzyl group played an important role.
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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及川 裕二
Faculty Of Pharmaceutical Sciences Hokkaido University
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米光 宰
岡山理大理
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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及川 裕二
北大薬
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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堀田 清
Faculty of Pharmaceutical Sciences, Hokkaido University
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長戸 哲
Faculty of Pharmaceutical Sciences, Hokkaido University
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堀田 清
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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長戸 哲
Faculty Of Pharmaceutical Sciences Hokkaido University
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