放射線障害防護薬剤に関する研究(第15報)インドール系化合物の放射線障害防護効力について

概要

論文の詳細を見る
Relationship between the chemical structure of 43 kinds of compounds, having indole and indoline as their fundamental skeleton, and their effect in protecting radiation damage was examined in mice irradiated with 800 R of X-rays, and the following facts were learned. 1) Tryptamine and many of its derivatives proved to have a radioprotective activity. 2) Compounds having acetonitrile, thioacetamide, or 2-aminothiazoline as the side chain in the 3-position were effective. 3) Some of the derivatives with 2-mercaptoethylamine side chain and 2-indolinethione-type compounds were effective as protectors. 4) Derivation of the side chain in the indole ring to the effective sulfur-containing group resulted in retardation of the appearance of the protective effect.
社団法人日本薬学会の論文
1974-12-25