実験的亜急性肝障害及び慢性肝障害に対する生薬メタノールエキスの効果

概要

論文の詳細を見る
The effects of 5 crude drugs (Myricae Cortex, Polygoni Avicularis Herba, Hyperici Erecti Herba, Forsythiae Fructus, Desmodii Herba) on subacute and chronic hepatic injuries induced by carbon tetrachloride (CCl_4) or α-naphthylisothiocyanate (ANIT) were investigated in rats. All of these crude drugs suppressed significantly the increase of several biochemical parameters with CCl_4-injection twice per week for 4 weeks. Polygoni Avicularis Herba and Desmodii Herba among 5 crude drugs also protected the subacute hepatic injury induced by ANIT-injection for 4 weeks. In addition, the therapeutic effect of Desmodii Herba on the chronic hepatic injury induced by CCl_4-injection for 9 weeks was recognized. Desmodii Herba has protective effects on the acute and subacute hepatic injuries induced by CCl_4 or ANIT and an improving effect on the chronic injury induced by CCl_4. Though the increase of hydroxylproline content in the liver began 4 weeks after the CCl_4 or ANIT treatment, every crude drug had no significant effect against the liver fibrosis in these study.
社団法人日本薬学会の論文
1992-03-25