利胆効力試験法の基礎的検討及び各種生薬のスクリーニング

概要

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By comparison of the choleretic effects of several kinds drugs, it was recognized that there exists a significant positive correlation between doses and the choleretic effects of sodium dehydrocholate and 1-phenylpropanol. Moreover, small differences in the amount of excretion of bile acid from bile were detected by use of these two drugs. It was also recognized to be suited in screening to utilize the rate of variation in the amount of bile acid to the values just before 120 min after the administration of drugs for the determination of their choleretic effects. As a result of screening in 17 out of 47 kinds of crude drugs high choleretic effects were detected. These drugs were classified into the following two groupes ; Hyperici erecti Herba, Forsythiae Fructus, Gardeniae Fructus, Gentianae Scabrae Radix, Atractylodis Rhizoma, Aurantii Percicarpium, Swertiae Herba, Plantaginis Semen and Desmodii Herba with a biliary bile acid increase and Ganoderma, Sophorae Radix, Valerianae Radix, Myricae Cortex, Acer nikoense, Scutellariae Radix, Curcumae Rhizoma and Patriniae Radix without a biliary bile acid increase.
公益社団法人日本薬学会の論文
1987-12-25