放射線障害防護薬剤に関する研究(第21報)軟X線によるマウスの皮膚障害を指標とする放射線障害防護薬剤の効力試験法の検討

概要

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Protective effect of 2-mercaptoethylamine against skin injury in mice by whole-body irradiation of soft X-ray of 30 kVp was measured to examine conditions for potency test with protective effect as an index, and the following results were obtained. 1) Intraperitoneal administration of 2.0-0.25 mmol/kg of 2-mercaptoethylamine in mice showed a significant protective effect on the head and dorsum, at a dose of 1.0 mmol/kg. 2) The optimum period of the administration of 2-mercaptoethylamine was found to be 30-5 min before irradiation. 3) Potency test with skin injury as an index calls for the measurement of protective potency on skin injury from the score obtained by observations during 40 days after irradiation of 4000-7000 R of soft X-ray of 30 kVp, 10 mA.
社団法人日本薬学会の論文
1979-06-25