O-Phosphoethanolamine のマウス骨髄細胞コロニー形成阻害作用の様式(生物学及び生化学)

概要

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O-Phosphoethanolamine (PEA) was previously shown to have potent colony inhibitory activity for mouse bone marrow cells in a medium composed of calf serum (CS). However, colony inhibitory activity of PEA decreased drastically in a medium composed of fetal calf serum (FCS) or heat treated CS. On the other hand, CS and FCS exhibited phosphatase activity which was heat labile and amine oxidase activity which was heat resistant, though amine oxidase activity of FCS was one-sixth of that of CS. And glycolaldehyde (GA) was detected in the incubation mixture of PEA and CS medium, but not in that of PEA and FCS medium. Ethanolamine (EA), a product of hydrolysis of PEA by phosphatase, inhibited colony formation in a medium composed of CS or heat treated CS, but not a medium composed FCS or heat treated FCS. GA, a product of oxidation of EA by amine oxidase, inhibited colony formation in any medium mentioned above. From these results, it is concluded that PEA is enzymatically converted into GA via EA, and GA thus formed inhibits colony formation.
社団法人日本薬学会の論文
1986-11-25