白血球調節因子に関する研究(第3報)パロチン, サリバ・パロチン・A, 副腎皮質刺激ホルモンおよび細菌性リポ多糖の白血球調節作用の比較

概要

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Leukocytosis-promoting response in rabbits was examined after intravenous injection of parotin, saliva parotin A, adrenocorticotropin (ACTH), or bacterial lipopolysaccharide (LPS-K_3). 1) Potency of the agents used was in approximate ratio of 1 : 100 : 1 : 2000 for parotin, saliva parotin A, ACTH, and LPS-K_3. 2) Continuous daily injection for 4 weeks resulted in the loss of reactivity except in the case of parotin. 3) When the rabbits with loss of reactivity to leukocytes by the continuous injection of saliva parotin A, ACTH, or LPS-K_3 for 3-4 weeks were injected with a different agent, similarity of the action was observed only in the combination of ACTH and LPS-K_3. In other combinations, leukocytosis-promoting response appeared, indicating that there is a difference in the action mechanism of these agents.
公益社団法人日本薬学会の論文
1976-04-25