Steroid Series. VII. Synthesis of 6-Methyl-B-norsteroids.
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概要
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3β, 5-Dihydroxy-6β-formyl-B-nor-5β-steroids (IIIa, b, c) of cholestane, pregnane, and androstane series were converted into the corresponding 3β, 5-dihydroxy-6β-methyl-B-nor-5β-steroids (VIa, d, e) by reduction of (III) with sodium borohydride, followed by tosylation of 6-hydroxymethyl group and subsequent treatment with lithium aluminium hydride. The compounds (VI) were oxidized to 3-oxo-5-hydroxy-6β-methyl-B-nor-5β-steroid derivatives (VIIa, b, f) which were then dehydrated to 6ξ-methyl-B-norcholest-4-en-3-one (VIIIa), 6ξ-methyl-B-norpregn-4-ene-3,20-dione (VIIIb), and 6ξ-methyl-B-norandrost-4-ene-3,17-dione (VIIIf).
- 公益社団法人日本薬学会の論文
- 1962-06-25
著者
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高崎 林治
Takamine Research Laboratory, Sankyo Co., Ltd.
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高崎 林治
Central Research Laboratories Sankyo Co. Ltd.
関連論文
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