Indomethacin Sustained-Release Suppositories Containing Sugar Ester in Polyethylene Glycol Base
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概要
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Indomethacin (IM) sustained-release suppositories were prepared by the fusion method using sugar ester and polyethylene glycol 4000 (PEG). The suppositories were evaluated by in vitro release testing, X-ray analysis and in vivo absorption testing in rabbits. X-ray analysis showed that IM was amorphous in PEG-base suppositories. In a release test, slow-release was obtained when the sugar ester content of a suppository was 60%. The IM plasma level following the administration of the suppository was well sustained in the absorption test. The main slow-release mechanism is considered to be the release of IM from the matrix composed of sugar ester and PEG, which is represented by the Higuchi equation. A good correlation between the release test and the absorption test was obtained. it is considered that the amorphous state of IM in this type of sustained-release suppository would enhance the release and absorption of IM in the rectum of the rabbit, whose rectal fluid volume is small.
- 1990-06-25
著者
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川島 嘉明
Gifu Pharmaceutical University
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小沢 康雄
Research Center, Taisho Pharmaceutical Co., Ltd.,
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高島 雍治
Research Laboratory, Taisho Pharmaceutical Co., Ltd.,
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中島 俊明
Research Center, Taisho Pharmaceutical Co., Ltd.,
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小沢 康雄
Research Center Taisho Pharmaceutical Co. Ltd.
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中島 俊明
Research Center Taisho Pharmaceutical Co. Ltd.
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古屋 淳
Research Center Taisho Pharmaceutical Co. Ltd.
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高島 雍治
Research Center Taisho Pharmaceutical Co. Ltd.
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