Particle Design of Tolbutamide by the Spherical Cystallization Technique. II. : Factors Causing Polymorphism of Tolbutamide Spherical Agglomerates
スポンサーリンク
概要
- 論文の詳細を見る
Tolbutamide (TBM) was agglomerated by several methods of spherical crystallization technique. A mixture of an ethanolic solution of TBM (II) and isopropyl acetate (III : bridging liquid) was added to water (I : crystallization solvent), and crystals were allowed to form. Agglomeration was then allowed to proceed while this system was stirred at 600 rpm. Next, I was added to a mixture of II and III; that is, the order of addition in the initial procedure was reversed, and crystallization-agglomeration was carried out. In addition, after adding I to II and causing the crystallization of TBM, III was added to the system to bring about agglomeration.These different crystallization-agglomeration techniques yielded TBM agglomerates having different crystalline forms, with a mixture of form A and form B obtained in the mixed solution of ethanol /water /isopropyl acetate (the first 2 methods described above) and form B obtained in the mixed solution of ethanol/water (the 3rd method). The composition ratio of the mixture of form A and form B crystals also differed as a function of the crystallization process. The findings of these experiments indicated that the causes of this difference in the composition ratio differ as a function of the course of changes in the composition of the TBM solution up to the point of agglomeration due to difference in the crystallization method. That is, it was elucidated that the crystalline form of the TBM agglomerate depends on the solvent environment (composition) at the time of formation of the crystal nuclei.
- 公益社団法人日本薬学会の論文
- 1989-08-25
著者
-
川島 嘉明
Gifu Pharmaceutical University
-
佐野 昭光
Pharma Research & Development Division Hoechst Japan Ltd.
-
竹内 洋文
Gifu Pharmaceutical University
-
丹羽 敏幸
岐阜薬科大学製剤学教室
-
丹羽 敏幸
Gifu Pharmaceutical University
-
栗木 武男
Pharma Research Laboratories, Hoechst Japan Limited
-
栗木 武男
ヘキストジャパン(株)
-
栗木 武男
Laboratory For Chemistry Hoechst Japan Limited
-
栗木 武男
Pharma Research And Development Division Hoechst Japan Limited
関連論文
- Particle Design of Enoxacin by Spherical Crystallizaion Technique. II. Characteristics of Agglomerated Crystals
- Particle Design of Enoxacin by Spherical Crystallization Technique. I. : Principle of Ammonia Diffusion System (ADS)
- ペプチドの経肺投与を目指した乳酸・グリコール酸共重合体(PLGA)ナノスフェアのエアロゾル化の検討
- B-11 表皮欠損部位における治療薬剤の製剤学的研究 (III) : 軟膏基剤の構造 (Oil droplet) に影響を及ぼす CyD 類と表面張力との関係について
- Mechanical Properties, Dissolution Behavior and Stability to Oxidation of L-Ascorbylmonostearate Microcapsules prepared by a Spray-Drying Polycondensation Technique
- Reactivity and Stability of Microencapsulated Placental Alkaline Phosphatase
- 肝細胞癌の塞栓療法のための塩酸エピルビシン封入w/o/w型リピオドールエマルションの設計
- Direct Agglomeration of Sodium Theophylline Crystals produced by Salting out in Liquid
- キトサンによるサスペンションコーティングにおける核粒子の設計と被膜制御
- 湿式球形造粒における造粒物の成長過程及び圧密化に及ぼす液体架橋剤の添加量の影響
- Computer Simulation of Agglomeration by a Two-Dimensional Random Addition Model. IV. : Agglomeration Kinetics and Micromeritic Properties of Agglomerate of Binary Mixtures of Adhesive Circles
- エマルション-溶媒拡散法による新規経口ドラッグデリバリ-システムのための機能性薬剤粒子の設計に関する研究
- Preparation of Prolonged-Release Spherical Micro-Matrix of Ibuprofen with Acrylic Polymer by the Emulsion-Solvent Diffusion Method for Improving Bioavailability
- Lyophilized Liposomes Prepared by a Modified Reversed-Phase Evaporation Method(Pharmaceutical)
- Crystal Modification of Phenytoin with Polyethylene Glycol for Improving Mechanical Strength, Dissolution Rate and Bioavailability by a Spherical Crystallization Technique
- Preparation of a Prolonged Release Tablet of Aspirin with Chitosan
- Preparation of a Directly Tabletable Controlled-Release Matrix Filler with Microcrystalline Cellulose Modified with Hydroxypropymethylcellulose
- Preparation of a Sustained-Release Matrix Tablet of Acetaminophen with Pulverized Low-Substituted Hydroxypropylcellulose via Dry Granulation
- Preparation of Powdered Redispersible Vitamin E Acetate Emulsion by Spray-Drying Technique
- Measurement of Diffusion Coefficients of Theophylline and Aminophylline in Carrageenan Gel
- 57(P1-5) (+)-ゼストキノンの全合成とその絶対構造の決定(ポスター発表の部)
- 65 新規ポリケタイド骨格を持つ(+)-ハレナキノールおよび(+)-ハレナキノンの全合成.理論計算によって決定した絶対構造の実験的証明(口頭発表の部)
- Indomethacin Sustained-Release Suppositories Containing Sugar Ester in Polyethylene Glycol Base
- Indomethacin Sustained-Release Suppositories Containing Sugar Ester
- Study on Absorption of Indomethacin from Sustained-Release Suppositories Containing Hydrogenated Soybean Lecithin in Rabbits
- Study on Slow-Release of Indomethacin from Suppositories Containing Hydrogenated Soybean Lecithin
- Preparation of Piretanide Polymorphs and Their Physicochemical Properties and Dissolution Behaviors
- Stability and Degradation Pattern of Cefpirome (HR 810) in Aqueous Solution
- Separation and Determination of Phospholipids in Plasma Employing Thin-Layer Chromatographic Plate with Concentration Zone or Solid Phase Extraction
- A Study of Embolizing Materials for Chemo-embolization Therapy of Hepatocellular Carcinoma : Effects of Particle Size and Dose on Chitin-Containing cis-Diamminedichloroplatinum (II) Albumin Microsphere Antitumor Activity in VX_2Hepatic Tumor Model Rabbits
- Size Control of Ibuprofen Microspheres with an Acrylic Polymer by Changing the pH in an Aqueous Dispersion Medium and Its Mechanism
- Studies on Xanthine Derivatives. I. Formation of Tricyclic Heterocycles from Hydrolysates of 1-(5-Oxohexyl) theobromine (Pentoxifylline)
- フロセミドのアルコール-水混合溶媒中における酸加水分解
- ペプチド封入乳酸・グリコール酸共重合体(PLGA)ナノスフェアの凍結乾燥による保存安定化
- MUCOADHESION OF POLYMER-COATED LIPOSOMES TO RAT INTESTINE IN VITRO
- Drug Release from the Water-in-Oil-in-Water Multiple Emulsion in Vitro. II. Effects of the Addition of Hydrophilic Surfactants to the Internal Aqueous Compartment on the Release Rate of Secretin
- Particle Design of Tolbutamide by the Spherical Crystallization Technique. V. Improvement of Dissolution and Bioavailability of Direct Compressed Tablets Prepared Using Tolbutamide Agglomerated Crystals
- Preparation of Powdered Phospholipid Nanospheres by Spray Drying in an Aqueous System with Sugars
- Particle Design for Antidiabetic Drugs by the Spherical Crystallization Technique. IV. Assessment of Compressibility of Agglomerated Tolbutamide Crystals Prepared by Crystallization Technique
- Stabilization of Water/Oil/Water Multiple Emulsion with Hypertonic Inner Aqueous Phase
- Preparation of Powdered Phospholipid Nanospheres by Fluidized-Bed Granulating in an Aqueous System with Sugars
- Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by Changing Their Intraparticle Porosity
- ナノサイズドラッグキャリアの設計法と実用化への展望
- Redispersible Dry Emulsion System as Novel Oral Dosage form of Oily drugs : In vivo Studies in Beagle Dogs
- エマルション-溶媒-拡散法による薬剤粉末の球形晶析造粒の挙動, プロセスの改良及び回分式閉回路システムの提案
- Particle Design of Tolbutamide by the Spherical Crystallization Technique. III. : Micromeritic Properties and Dissolution Rate of Tolbutamide Spherical Agglomerates Prepared by the Quasi-Emulsion Solvent Diffusion Method and the Solvent Chenge Method
- Particle Design of Tolbutamide by the Spherical Cystallization Technique. II. : Factors Causing Polymorphism of Tolbutamide Spherical Agglomerates
- Studies on Oxygen Determination by the Carrier Gas Method. IX. Determination of Oxygen in Thallium and Thallium Compounds
- 第60回有機微量分析研究懇談会シンポジウム
- Synthesis of Imidazo[4,5-c][1,2,6]thiadiazine 2-Oxides from Hydrolytes of Xanthines and Determination of Their Vasodilating Activity
- Synthesis of Imidazo[4,5-e][1,4]diazepine and Imidazo[4,5-e][1,4]-oxazepine Derivatives Using Caffeidine, a Hydrolysis Product of Caffeine
- Studies on Xanthine Derivatives. II. : Synthesis of 1,2,3,7-Tetrahydro-6H-purin-6-ones from Xanthine Hydrolyzates
- Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. III. : Changes of Agglomerate Structure in a Two-Dimensional System with Anionic Surface-Acitive Agent
- Flocculation Kinetics of the Didisperse System-Computer Simulation of Flocculation by the Random Coalescence Model
- Effects of Granulation Method and Drug Dissolved in Binder Solution on Compressibility of Granules
- Spray Drying Agglomeration. I. Physicochemical Properties of Agglomerated Synthetic Aluminium Silicate or Magnesium Carbonate
- Wet Spherical Agglomeration of Binary Mixtures. II. Mechanism and Kinetics of Agglomeration and the Crushing Strength of Agglomerates
- Computer Simulation of Agglomeration by a Two-dimensional Random Addition Model. III. -Agglomeration Kinetics and Micromeritic Properties of Closely-packed Agglomerates of Heterogeneous Binary Circles-
- Simulation of Agglomeration. II. Two-dimensional Random Addition Model. (1)
- SPHERICAL AGGLOMERATION OF AMINOPHYLLINE CRYSTALS DURING REACTION IN LIQUID BY THE SPHERICAL CRYSTALLIZATION TECHINIQUE
- The Role of Binders in the Prevention of Capping within a Tablet
- Introduction of New Index for the Prediction of Capping Tendency of Tablets
- The Effects of Interfacial Physical Properties on the Cohesive Forces of Moist Powder in Air and in Liquid
- The Effects of Wall Thickness and Amount of Hardening Agent on the Release Characteristics of Sulfamethoxazole Microcapsules prepared by Gelatin-Acacia Complex Coacervation