Redispersible Dry Emulsion System as Novel Oral Dosage form of Oily drugs : In vivo Studies in Beagle Dogs
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概要
- 論文の詳細を見る
The absorption characteristics of vitamin E acetate (VEA) formulated into a dry emulsion system after its oral administration to beagle dogs were determined and compared to those of two different dosage forms (an oily mixture of the drug with cottonseed oil and an oil (drug)-in-water emulsion). The three dosage forms were administered in a crossover fashion to six nonfasting subjects, and the drug absorption was assessed from the plasma concentration of the major metabolite (free vitamin E). VEA formulated in the dry emulsion was rapidly absorbed, which suggested that a considerable amount was released as reformed emulsion droplets in the gastrointestinal tract as well as in water in vitro. Based on the analysis of variance, no significant differences in bioavailability parameters (AUC, C_<max> or T_<max>) were observed among the three dosage forms.
- 公益社団法人日本薬学会の論文
- 1991-12-25
著者
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川島 嘉明
Gifu Pharmaceutical University
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小澤 博
Research Laboratories Of Pharmaceutical Development Eisai Co. Ltd.
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上杉 恵三
エーザイ株式会社臨床研究センター薬物応用研究部臨床分析室:(現)エーザイ株式会社品質保証部品質保証室
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上杉 恵三
エーザイ株式会社薬物応用研究部臨床分析室
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竹内 洋文
Gifu Pharmaceutical University
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丹羽 敏幸
岐阜薬科大学製剤学教室
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丹羽 敏幸
Gifu Pharmaceutical University
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日野 知証
Gifu Pharmaceutical University
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佐々木 秀人
Gifu Pharmaceutical University
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上杉 恵三
Research Laboratories, Eisai Co., Ltd.
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