Biopharmaceutical Studies on Guaiacol Glycerol Ether and Related Compounds. III. Metabolites of Guaiacol Glycerol Ether and Its Mononicotinate.
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概要
- 論文の詳細を見る
Metabolites of guaiacol glycerol ether and its mononicotinate in rabbit urine were investigated. As the metabolites of guaiacol glycerol ether, β-(2-methoxyphenoxy) lactic acid, (2-methoxyphenoxy) acetic acid, β-(4-hydroxy-2-methoxyphenoxy) lactic acid, and (4-hydroxy-2-methoxyphenoxy) acetic acid (trace) were separated with unchanged GGE, and identified with the authentic samples by thin-layer chromatography. Two of the metabolites, β-(4-hydroxy-2-methoxyphenoxy) lactic acid and (4-hydroxy-2-methoxyphenoxy) acetic acid showed hypocholesteremic action on hypercholesteremia caused by intravenous injection of Triton to rats. As metabolites of guaiacol glycerol ether in rabbit liver and kidney in vitro, only β-(2-methoxyphenoxy) lactic acid was detected with the unchanged drug by thin-layer chromatography.
- 社団法人日本薬学会の論文
- 1969-09-25
著者
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内藤 俊一
Kyoto College Of Pharmacy
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水谷 光雄
Kyoto College Of Pharmacy
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西村 幸子
Kyoto College Of Pharmacy
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北尾 和彦
Kyoto College of Pharmacy
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北尾 和彦
Kyoto Pharmaceutical Industries Ltd.
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