ENHANCEMENT OF NEURAMINIDASE ACTIVITY WITH INFLUENZA VIRUS BY ANTI-INFLUENZA VIRUS DRUG
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概要
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The influence of anti-influenza virus drugs on the neuraminidase activity with three influenza virus strains was examined.When the allantoic fluid infected with influenza virus strains (A0/PR8, A2/Adachi and B/Lee) was treated with 1-adamantanamine hydrochloride (amantadine), the neuraminidase activity was significantly enhanced in all three influenza virus strains. The B/Lee strain exhibited the highest enhancement of neuraminidase activity after 1-adamantanamine hydrochloride treatment.When purified virus, enzyme source, was treated with various concentrations of 1-adamantanamine hydrochloride, the enhancement of neuraminidase activity with A0/PR8 strain was observed even at a lower concentration (0.1-400 μg/ml) and the activity further increased with increasing concentration of the drug and reached a plateau at the level of 600-1200 μg/ml. On the other hand, the enhancement of neuraminidase activity with the A2/Adachi strain was maximum at about 1 μg/ml of 1-adamantanamine hydrochloride.Treatment with isoquinoline derivatives resulted in the enhancement of neuraminidase activity with the A0/PR8 and A2/Adachi strains at a lower concentration, but at a higher concentration, one of the isoquinoline derivatives, UK 2371-01, presented an inhibitory effect.Our results suggest that the enhancement of neuraminidase activity with the influenza viruses may be a converse action to viral inhibitory activity of anti-influenza virus drugs.
著者
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Fukushima Koji
Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University
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Toyoshima Shigeshi
Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University
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