Canine X-Linked Muscular Dystophy in Japan(CXMD_)
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to develop a strain of canine X-linked muscular dystrophy (CXMD), a model of Duchenne muscular dystrophy, in Japan. A female beagle was artificially inseminated with frozen-thawed spermatozoa derived from an affected golden retriever. Subsequently, two carrier female dogs (G1 carriers) and four normal male littermates were produced. Thereafter, the two G1 carriers were mated with beagle sires. As a result, each bitch whelped three times, and out of 54 pups, 17 affected male descendants, and 11 carrier female descendants (G2 carriers) were detected. One G2 carrier was then mated with a beagle sire and 15 pups in two whelpings were produced, including five affected males and four carrier females (G3 carriers). A total of 10 female beagles were artificially inseminated to evaluate the fertility of the frozen-thawed spermatozoa from the two affected dogs. The whelping rates of the two affected dogs were 4/5 and the litter sizes were 5.0 ± 1.41 and 6.0 ± 0.82, respectively. These results indicate that a canine X-linked muscular dystrophy colony has been established in Japan. We called them CXMDJ.
- 社団法人 日本実験動物学会の論文
- 2003-04-01
著者
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TANIOKA YOSHIKUNI
Central Institute for Experimental Animals
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KATAGIRI Kouichi
Chugai Research Institute for Medical Science, Inc.
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NONAKA Ikuya
National Center for Neurology and Psychiatry
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Tomohiro Masayuki
National Institute Of Neuroscience National Center Of Neurology And Psychiatry
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Katagiri K
Chugai Research Institute For Medical Science Inc
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Tanioka Yoshikuni
Central Institute For Experimenttal Animals
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Nonaka Ikuya
National Center Hospital For Mental Nervous And Muscular Disorders National Center Of Nertology And
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Nonaka Ikuya
National Center For Nervous. Mental And Musculor Disorders
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Katagiri Koichi
Chugai Research Institute For Medical Science
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SHIMATSU Yoshiki
Chugai Research Institute for Medical Science, Inc
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FURUTA Toshio
Chugai Research Institute for Medical Science, Inc
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NAKURA Masao
Chugai Research Institute for Medical Science, Inc
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YUASA Katsutoshi
National Institute of Neuroscience, National Center of Neurology and Psychiatry
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KORNEGAY Joe
Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia
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Takeda Shin'ichi
National Institute Of Neuroscience National Center Of Neurology And Psychiatry
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Shimatsu Y
Chugai Research Institute For Medical Science Inc
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Katagiri Kouichi
Chugai Research Institute For Medical Science Inc
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FURUTA Toshio
CSK Research Park, Inc.
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Nakura Masao
Chugai Research Institute For Medical Science Inc
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Furuta Toshio
Chugai Research Institute For Medical Science Inc
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Shimatsu Yoshiki
Chugai Research Institute For Medical Science Inc
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Yuasa Katsutoshi
National Institute Of Neuroscience National Center Of Neurology And Psychiatry
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Kornegay Joe
Department Of Physical Medicine And Rehabilitation University Of Missouri-columbia
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NAKURA Masao
Chugai Pharmaceutical Co., Ltd.
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