Standardized Data and Relationship between Bone Growth and Bone Metabolism in Female Gottingen Minipigs
スポンサーリンク
概要
- 論文の詳細を見る
Minipigs have been studied as a model of osteoporosis. However, little information is available regarding their bone physiology. We established standardized bone data and investigated the relationship between bone growth and bone metabolism in female minipigs. Blood and urine samples were obtained from 53 female Göttingen minipigs, 3-76 months of age, for measurement of bone biomarkers (i.e., BAP, OC, NTX, and DPD). The lumbar vertebra and femur were excised to determine the growth plate condition, bone length, bone mineral content (BMC), and bone mineral density (BMD). High levels of bone biomarkers were observed during the initial period after birth, decreasing thereafter with age. Bone biomarkers were confirmed to be highly correlated with age (R2 > 0.7). The growth plates of the lumbar vertebra and the femur began to close at 21 and 25 months of age, respectively, and closed completely at 42 months of age. Bone length increased rapidly before growth plate closure, and reached a peak at 21 and 28 months of age in the lumbar vertebra and the femur, respectively. The levels of BMC and BMD increased rapidly before growth plate closure, and continued to increase slowly until 76 months of age. A high negative correlation (-0.855 < r < -0.711, p<0.001) was confirmed between the bone biomarkers and the bone measurement data. These results indicate that the bone turnover velocity is consistent with the bone growth velocity in female Göttingen minipigs.
- 社団法人 日本実験動物学会の論文
著者
-
Tsutsumi H
Chugai Res. Inst. Medical Sci. Inc. Nagano Jpn
-
Tanigawa Manabu
Chugai Research Institute For Medical Science
-
Tsutsumi Hideki
The United Graduate School Of Veterinary Sciences Yamaguchi University
-
Nasu Tetsuo
The United Graduate School Of Veterinary Sciences Yamaguchi University
-
MAMBA Koichi
The United Graduate School of Veterinary Science, Yamaguchi University
-
Mamba K
The United Graduate School Of Veterinary Sciences Yamaguchi University
-
Mamba Koichi
Veterinary Sciences Yamaguchi University School Of Medicine
-
Katagiri Koichi
Chugai Research Institute For Medical Science
-
TAKEDA Satoshi
Pharmaceutical Research Dept. 2, Chugai Pharmaceutical Co. Ltd.
-
IGARASHI Sinichi
Chugai Research Institute for Medical Science
-
Katagiri Kouichi
Chugai Research Institute For Medical Science Inc
-
Takeda S
Pharmaceutical Research Dept. 2 Chugai Pharmaceutical Co. Ltd.
関連論文
- Granulocyte Colony-Stimulating Factor Has No Adverse Effects on Atherosclerotic Lesions in High Cholesterol-Fed Miniature Swine(Pathology)
- Availability of miniature pigs for the evaluation of cardiovascular system affected by drugs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- 21B-03-5 Experimental Technology of Percutaneous Toxicity Test in Miniature Swine;Experimental Procedures.
- 21B-03-4 Utilization of Miniature Swine for Percutaenous Toxicity Evaluation of Vitamin D_3 Analog
- Effects of Pair Housing on Diurnal Rhythms of Heart Rate and Heart Rate Variability in Miniature Swine
- Age-related changes of bone mineral density and microarchitecture in miniature pigs
- Fibrin Stimulates the Proliferation of Human Keratinocytes through the Autocrine Mechanism of Transforming Growth Factor-α and Epidermal Growth Factor Receptor
- NUCLEOTIDE SEQUENCE DETERMINATION AND EXPRESSION OF BOVINE MITOCHONDRIAL ATP-DEPENDENT PROTEASE(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Establishment and characterization of in vivo human tumor models in the NOD/SCID/γ_c^ mouse
- Canine X-Linked Muscular Dystophy in Japan(CXMD_)
- Standardized Data and Relationship between Bone Growth and Bone Metabolism in Female Gottingen Minipigs
- ビーグルにおけるLHサージを指標とした自然交配および凍結-融解精子の人工受精による繁殖成績