Contact Dermatitis Induced by Chemicals for Hair-dyeing in Hairless Dogs
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概要
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Dermatotoxicity of topical application of chemicals for hair-dyeing (CHD) was clinically and histopathologically investigated in hairless dogs. CHD examined were as follows: 1. Resorcinol (RCL), 2. pyrogallol (PGL), 3. tolylene-3, 4-diamine (T34D), 4. tolylene-2, 4-diamine (T24D), 5. ammonium persulfate (AMPS), 6. potassium persulfate (PTPS), 7. hydrogen peroxide (HDPO), and 8. vehicle (control). Severe contact dermatitis characterized by swelling, intense edema, and blister formation was seen at 4 or 5 days application of PGL. Test sites applying T34D and T24D showed striking contact dermatitis from 7 to 10 days application. Especially, the T34D-applying sites showed prominently edematous vesicular reactions followed by moderate pigmentation. At the test site applying AMPS provoked delayed contact dermatitis. At the test sites applying HDPO, severe dermatitis was immediately exhibited. Histopathologically, test sites applying RCL showed remarkable hyperkeratosis. At the test site 5 days application of PGL, intraepidermal blisters contained abundant inflammatory cells. At the test site 10 days application of T34D and T24D, prominent hypertrophy of epidermal cells and infiltration of inflammatory cells in the dermis were observed. These histopathological findings were severer in the test sites applying T34D than T24D. At the site 40 days after the end of topical application of T34D, a few epidermal cells with pyknotic nuclei and eosinophilic cytoplasma were seen in some repairing epithelium. By 40 days after the end of application of T34D, pigmentation was observed in the stratum basale and spinosum. From 20 to 30 days application of AMPS, focal necrosis in the dermal-epidermis junction was noted. In the dermis, prominent inflammatory changes were observed. At the test site 5 days application of HDPO, the epidermis was thickened by intracellular edema and hyperplasia of component cells. Additionally, the epidermis showed prominent parakeratosis. These results revealed that the skin of hairless dogs gave a definitive response to topical application of CHD. Hairless dogs were suggested for laboratory animals to evaluate immediate-and/or delayed-type dermatotoxicity of CHD.
- 日本毒性病理学会の論文
- 1999-03-01
著者
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Doi Kunio
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Kimura Tohru
Research Center Nihon Nosan Kogyo Co. Ltd.
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