Several Environmental Pollutants Have Binding Affinities for Both Androgen Receptor and Estrogen Receptor α
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概要
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We determined the binding affinities of some chemicals suspected of having endocrine-disrupting effects for androgen and/or estrogen receptors (ADR and ERα) by a non-radioisotope (RI) receptor binding assay. Tributyltin had the highest binding affinity for ADR with an IC_<50> of 7.6×10^<-6> M, but no affinity for ERα. Bisphenol A and 4-nonylphenol strongly bound to both ADR (IC_<50> values of 7.9×10^<-6> and 1.3×10^<-5> M, respectively) and ERα (IC_<50> values of 7.8×10^<-6> and 7.2×10^<-7> M, respectively). Octachlorostyrene had affinity for both receptors (IC_<50> for ADR, 2.7×10^<-5> M; and for ERα, 7.0×10^<-5> M). Although 4-octylphenol had a low affinity for ADR, it had a high affinity for ERα (IC_<50> of 9.8×10^<-6> M). Di-n-butyl phthalate, dicyclohexyl phthalate, and di(2-ethylhexyl) phthalate had low affinities for both ADR and ERα. The affinity of benzophenone was low for both receptors and n-butylbenzene had no affinity for either. Styrene trimers such as 1a-phenyl-4a-(1'-phenylethyl)tetralin (ST-2), 1a-phenyl-4e-(1'-phenylethyl)tetralin (ST-3), 1e-phenyl-4a-(1'-phenylethyl)tetralin (ST-4), and 1e-phenyl-4e-(1'-phenylethyl)tetralin (ST-5) had relatively high affinities, with IC_<50> values of 1.2-3.1×10^<-5> M. Styrene dimers showed lower affinities for ADR than the trimers. Some styrene oligomers have been previously reported to have binding affinities for ERα. These findings suggest that some chemicals possess binding affinities for ADR and ERα. It is necessary to examine the effects of substances on various hormone receptors to elucidate their endocrine-disrupting activities.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
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SATOH Kanako
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Satoh Kanako
東京都健康安全研究センター
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Satoh Kanako
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Satoh Kanako
Department Of Toxicology The Tokyo Metropolitan Research Laboratory Of Public Health
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Satoh Kanako
東京都立衛生研究所
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NAGAI Fumiko
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Aoki Naoto
Department of Toxicology, The Tokyo Metropolitan Research Laboratory of Public Health
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Aoki Naoto
Department Of Cardiology Tokai University Hospital
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Aoki Naoto
Department Of Toxicology The Tokyo Metropolitan Research Laboratory Of Public Health
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Nagai Fumiko
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Aoki Naoto
Department of Applied Physics, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan
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