DETERMINATION OF OXYCODONE METABOLITES IN URINES AND FECES OF SEVERAL MAMMALIAN SPECIES
スポンサーリンク
概要
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Determination of oxycodone metabolites excreted in urines and feces of several mammalian species was studied by use of the tritium labeled compound. It was found that the radioactivity was excreted more in the urines than in the feces in rabbits, guinea pigs and mice, but not in rats, who eliminated it equally into the urines and feces. Most of the radioactivity was excreted in 48 h after the administration. Seven metabolites, oxymorphone, 6α-oxycodol, 6/β-oxycodol, 7/β-hydroxy-6/β-oxycodol, noroxycodone, oxycodone N-oxide, and 6α-oxycodol , N-oxide, as well as unchanged oxycodone, were found to be excreted into urines of rabbits in both free and conjugated forms except two N-oxides, which were found only in the free form. It was discussed that analgesic effect of oxycodone would mainly be attributable to the oxycodone itself, but not to the metabolites.
- 公益社団法人日本薬学会の論文
著者
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Ishida Takashi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Ishida Takashi
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)faculty Of Pharmaceutical Scie
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