SELECTIVE INDUCTION OF RAT LIVER MICROSOMAL CYTOCHROME P-448 BY 3,4,5,3', 4'-PENTACHLOROBIPHENYL AND ITS EFFECT ON LIVER MICROSOMAL DRUG METABOLISM
スポンサーリンク
概要
- 論文の詳細を見る
Pretreatment of rats with 3,4,5,3', 4'-pentachlorobiphenyl (PenCB) at a single i.p. dose of 10 mg/kg caused a marked increase of cytochrome P-448 (P448) in liver microsomes. The liver microsomes of PenCB-treated rats (PenCB-microsomes) showed similar but somewhat different properties from those of 3-methylcholanthrene (MC)-treated rats (MC-microsomes) with respect to its CO difference spectrum, electrophoretic pattern on sodium dodecyl sulfate (SDS)-polyacrylamide gel and immunochemical reactivity with the antibodies prepared against the hemoproteins from phenobarbital (PB)- or β-naphthoflavone (BNF)-treated rat liver microsomes. Furthermore, PenCB pretreatment decreased not only demethylation of aminopyrine and codeine, but also hydroxylation of aniline, to which PenCB-microsomes showed lower affinity than MC-microsomes. Trace amounts of PenCB inhibited the metabolism of aniline and aminopyrine by MC-microsomes but not by untreated rat liver microsomes. On SDS-polyacrylamide gel electrophoretograms the ratio of cytochrome P450 (P450) to P448 in PenCB-microsomes was much smaller than that in MC-microsomes. These results may suggest that a part of the differences between the catalytic properties of PenCB- and MC-microsomes is due to the inhibitory effect of residual PenCB in PenCB-microsomes or/and the marked change of a relative ratio of P450 to P448 in PenCB-microsomes. A possibility that PenCB may induce a different P448 from that induced by MC is also discussed.
- 公益社団法人日本薬学会の論文
著者
-
Ozawa Naoki
Faculty Of Pharmaceutical Sciences Kyushu University
-
Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Yoshihara Shinichi
Faculty Of Pharmaceutical Sciences Kyushu University
関連論文
- FURTHER STUDIES ON SULFOXIDE-REDUCING ENZYME SYSTEM
- COMPOSITION AND PROPERTIES OF SULFOXIDE-REDUCING ENZYME SYSTEMS
- SULFOXIDE-REDUCING ENZYME SYSTEMS
- METABOLISM IN VITRO OF SULINDAC. SULFOXIDE-REDUCING ENZYME SYSTEMS IN GUINEA PIG LIVER
- STUDIES ON METABOLIC ACTIVATION OF NITROFURANS : FORMATION OF ACTIVE METABOLITES AND THEIR BINDING TO CYSTEINE AND GLUTATHIONE
- RELATIONSHIP BETWEEN BIOLOGICAL ACTIVITIES AND ENZYMATIC REDUCTION OF NITROFURAN DERIVATIVES
- Site-Selective Oxidation of Strychnine by Phenobarbital Inducible Cytochrome P-450
- SITE-SELECTIVE OXIDATION OF STRYCHNINE BY PHENOBARBITAL INDUCIBLE CYTOCHROME P-450
- Species Difference in Metabolism of Strychnine with Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits and Dogs
- METABOLIC FATE OF STRYCHNINE IN VITRO
- MECHANISM OF SLEEP-PROLONGATING EFFECT OF Δ^8-TETRAHYDROCANNABINOL (Δ^8-THC) AND ITS METABOLITES
- IDENTIFICATION AND DETERMINATION OF 11-OXO-Δ^8-TETRAHYDROCANNABINOL AS AN INTERMEDIATE METABOLITE OF Δ^8-TETRAHYDROCANNABINOL IN THE MOUSE BRAIN AND LIVER
- UDP-GLUCURONYLTRANSFERASE ACTIVITIES OF RABBIT LIVER MICROSOMES FOR CANNABINOIDS
- METABOLIC CONVERSION OF Δ^8-TETRAHYDROCANNABINOL (Δ^8-THC) TO Δ^8-THC-11-OIC ACID AND ITS PHARMACOLOGICAL IMPLICATIONS
- METABOLISM OF 11-HYDROXY-Δ^8-THC TO 11-OXO-Δ^8THC IN RATS (The Fourth Meeting for the Study of Toxic Effect)
- Inhibitory Effect of Cannabidiol Hydroxy-quinone, and Oxidative Product of Cannabidiol, on the Hepatic Microsomal Drug-Metabolizing Enzymes of Mice
- INTERACTION OF CANNABINOIDS WITH HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM IN THE RAT
- EFFECTS OF TWO CANNABINOIDS ON HEPATIC MICROSOMAL CYTOCHROME P-450
- METABOLIC ACTIVATION OF Δ^8-THTRAHYDROCANNABINOL (Δ^8-THC) AT THE 7-POSITION AND MECHANISM OF THE OXIDATION OF 7-HYDROXY-Δ^8-THC TO 7-OXO-Δ^8-THC WITH LIVER MICROSOMES
- IN VITRO METABOLISM OF TETRAHYDROCANNABINOL (THC) BY HUMAN LIVER MICROSOMES. EPOXIDE-DIOL PATHWAY OF THC
- THE PROPERTIES OF UDP-GLUCURONYLTRANSFERASE FOR CANNABINOIDS IN RAT LIVER MICROSOMES
- TOXICOLOGICAL ASSESSMENT OF POLYCHLORINATED DIBENZOFURANS (PCDF). I. RELATIONSHIP BETWEEN INDUCTIVE EFFECTS ON HEPATIC ENZYMES AND TOXICITIES OF PURE PCDF CONGENERS RETAINED IN YUSHO PATIENTS
- EFFECT OF LIVER S9 FROM 3,4,5,3', 4'-PENTACHLOROBIPHENYL-PRETREATED RATS ON THE MUTAGENIC ACTIVITY OF THE VARIOUS CARCINOGENS TOWARD SALMONELLA TYPHIMURIUM TA 98
- Metabolism in Vivo of 3,4,5,3', 4'-Pentachlorobiphenyl and Toxicological Assessment of the Metabolite in Rats
- Acute Toxicity and Inductive Effect on Liver Enzymes of 3,4,5,3', 4'-Pentachlorobiphenyl in Chickens (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- STUDIES ON CIS-TRANS ISOMERIZATION OF NITROFURAN DERIVATIVES BY BACTERIAL NITROREDUCTASES
- STUDIES ON THE METABOLISM OF NITROFURAN DERIVATIVES IN BACTERIA : PROPERTIES OF CIS-TRANS ISOMERASES AND NITROREDUCTASES, AND RELATIONSHIP OF THESE ENZYMES
- STUDIES ON ENZYMIC CIS-TRANS ISOMERIZATION OF NITROTHIOPHENE AND NITROBENZENE DERIVATIVES
- Enhanced Elimination of Theophylline, Phenobarbital and Strychnine from the Bodies of Rats and Mice by Squalane Treatment
- PURIFICATION AND CHARACTERIZATION ON 3,4,5,3', 4'-PENTACHLOROBIPHENYL-INDUCIBLE CYTOCHROME P-450 IN CHICKEN LIVER
- Mechanisms of Stimulated Fecal Excretion of Polychlorinated Aromatic Hydrocarbons in Rats
- Metabolic Activation and Detoxication of Polychlorinated Biphenyls
- IN VIVO METABOLITES OF 3,4,3', 4', -TETRACHLOROBIPHENYL AND THE TOXICOLOGICAL ASSESSMENT IN RATS
- OXYGEN-INSENSITIVE NITROFURAN REDUCTASES IN SALMONELLA TYPHIMURIUM TA100
- ISOLATION AND IDENTIFICATION OF THE METABOLITE OF N-(5-NITRO-2-FURFURYLIDENE)-3-AMINO-2-OXAZOLIDONE (FURAZOLI-DONE)
- Major Metabolites of Ginseng Sapogenins formed by Rat Liver Microsomes
- Induction of a High-Spin Form of Cytochrome P-450 by Highly Toxic Polychlorinated Aromatic Hydrocarbons (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Cellular Uptake of 2,3,4,7,8-Pentachlorodibenzofuran in the Rat Liver (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- ACCUMULATION, EXCRETION AND EFFECTS ON HEPATIC ENZYMES OF POLYCHLORINATED QUATERPHENYL CONGENERS IN RATS
- Intracellular Distribution and Binding to Cytosolic Protein of 2,3,4,7,8-Pentachlorodibenzofuran in the Liver of Rats (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- HIGH ACCUMULATION OF 2,3,4,7,8-PENTACHLORODIBENZOFURAN TO HEPATIC MICROSOMES OF RATS
- Extremely High Affinity of 2,3,4,7,8-Pentachlorodibenzofuran for Hepatic Microsomes of Rats (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- Effect of 3-Methylcholanthrene-and Phenobarbital-Type Polychlorinated Biphenyls (PCBs) on the Liver Soluble Enzymes of Rats (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- Enhancement of Reduction Activity of 4NQO in Animals pretreated with 3-Methylcholanthrene-type PCB and PCDF (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Photodecomposition and Bioconcentration of a Bisphenol A Metabolite in Medaka, Oryzias latipes
- Enzymatic Hydroxylation of Tetrachlorobiphenyls in Rats
- Metabolism in Vitro of 3,4,3', 4'- and 2,5,2', 5'-Tetrachlorobiphenyl by Rat Liver Microsomes and Highly Purified Cytochrome P-450
- Liver Cytochrome P-450 Isozyme Responsible for the Metabolism of Tetrachlorobiphenyls in Rat (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Inhibition of Cytochrome P-448H Dependent Catalytic Activity by 3,4,5,3', 4'-Pentachlorobiphenyl (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- EFFECT OF CO-ADMINISTRATION OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, WITH SKF 525-A ON HEPATIC DRUG METABOLIZING ENZYMES OF RATS
- SUPPRESSIVE MECHANISM OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, ON THE INDUCTION OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES
- SUPPRESSIVE EFFECT OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID ON INDUCTION OF URIDINE DIPHOSPHATE-GLUCURONYLTRANSFERASES AND MONOOXYGENASES IN LIVER MICROSOMES OF RATS
- UNIQUE INDUCTION OF CYTOCHROME P-450 ISOZYMES IN RAT LIVER MICROSOMES BY TREATMENT WITH 3,4,5,3', 4'-PENTACHLOROBIPHENYL AND ITS EFFECT ON TESTOSTERONE METABOLISM
- EFFECT OF COBALTOUS CHLORIDE-TREATMENT ON DRUG METABOLIZING ENZYMES AND TOXICITES INDUCED BY METHYLCHOLANTHRENE-TYPE PCB
- SUPPRESSION BY INTERFERON INDUCER ON INDUCTION OF MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES IN LIVER MICROSOMES OF RATS
- CORRELATION BETWEEN A UNIQUE CHANGE OF STEROID METABOLISM AND CYTOCHROME P-450 INDUCED BY PRETREATMENT WITH 3-METHYLCHOLANTHRENE-TYPE PCB AND PCDF
- SUPPRESSION OF THE INDUCTION OF RAT LIVER MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES BY HEMATIN AND COBALTOUS CHLORIDE
- MECHANISM OF TOXICITY PRODUCED BY 3-METHYLCHOLANTHRENE-TYPE PCBS (2) : EFFECTS OF PCBS AND RELATED COMPOUNDS ON THE METABOLISM OF STEROIDS
- NOVEL COLUMN CHROMATOGRAPHY PROCEDURE FOR THE PURIFICATION OF UDP-GLUCURONYLTRANSFERASES
- EFFECT OF ENDOTOXIN ON INDUCTION OF MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES IN RAT HEPATIC MICROSOMES
- A Candidate Anti-Prion Disease Agent, 2,2-Biquinoline, Decreases Expression of Prion Protein and mRNA in Prion-Infected Cells
- Species Difference of Site-Selective Glucuronidation of Morphine
- Species Difference in Codeine Uridine Diphosphate-Glucuronyltransferase Activity of Liver Microsomes
- SPECIES DIFFERENCE OF SITE-SELECTIVE GLUCURONIDATION OF MORPHINE
- Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes
- DECREASED URINARY EXCRETION OF THIAMINE PROPYL DISULFIDE METABOLITES IN PATIENTS WITH LIVER DISEASE
- DETERMINATION OF URINARY METABOLITES OF THIAMINE PROPYL DISULFIDE IN HUMANS
- A UNIQUE CHANGE OF STEROID METABOLISM IN RAT LIVER MICROSOMES INDUCED WITH HIGHLY TOXIC POLYCHLORINATED BIPHENYL(PCB) AND POLYCHLORINATED DIBENZOFURAN(PCDF)
- CHEMICAL ANALYSIS AND TOXICITY OF POLYCHLORINATED BIPHENYLS AND DIBENZOFURANS IN RELATION TO YUSHO
- DIFFERENT RESPONSIVENESS OF HEPATIC AND PULMONARY MICROSOMAL MIXED FUNCTION OXIDASES TO PHENOBARBITALTYPE AND 3-METHYLCHOLANTHRENE-TYPE POLYCHLORINATED BIPHENYLS IN RATS
- MECHANISM OF TOXICITY PRODUCED BY 3-METHYLCHOLAN-THRENE-TYPE PCBs (1)
- THE MECHANISM OF N-DEMETHYLATION OF METHAMPHETAMINE BY LIVER MICROSOMES : THE ROLE OF FLAVIN CONTAINING MONOOXYGENASE AND CYTOCHROME P-450 SYSTEMS
- METABOLISM AND NEPHROTOXICITY OF PHENACETIN AND SULFANILAMIDE
- METABOLISM AND NEPHROTOXICITY OF PHENACETIN AND SULFANILAMIDE
- ENHANCEMENT OF SULFANILAMIDE N^4-HYDROXYLASE ACTIVITY IN KIDNEY AND LIVER MICROSOMES OF RATS BY PRETREATMENT WITH 3-METHYLCHOLANTHRENE TYPE-POLY-CHLORINATED BIPHENYL
- 120. OXIDATIVE ENZYME SYSTEM OF 11-HYDROXY Δ^8-THC (ACTIVE METABOLITE OF Δ^8-THC) IN HEPATIC MICROSOMES (The Third Meeting for the Study of Toxic Effect)
- SPECIES DIFFERENCE OF UDP-GLUCURONYLTRANSFERASE ISOZYMES IN LIVER MICROSOMES
- Stimulating Effect of Liquid Paraffin and Cholestyramine on Fecal Excretion of 2,3,4,7,8-Pentachlorodibenzofuran in Rats (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- ALTERED THIAMINE PROPYL DISULFIDE METABOLISM IN RATS WITH LIVER INJURY INDUCED BY CARBON TETRACHLORIDE AND D-GALACTOSAMINE
- TOLERANCE DEVELOPMENT TO HYPOTHERMIC EFFECT OF Δ^8-TETRAHYDROCANNABINOL AND ITS ACTIVE METABOLITES
- THE CONTRIBUTION OF 6-ACETYL GROUP TO PHARMACOLOGICAL EFFECTS OF 6-ACETYLMORPHINE, AN ACTIVE METABOLITE OF HEROIN
- Involvement of Microsomal Aldehyde Oxygenase (MALDO) in the Metabolism of Aliphatic Aldehydes in the Mouse Liver (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- UDP-GLUCURONYLTRANSFERASES IN MICE BRAIN AND THE INDUCIBILITY
- B-16 SUBSTRATE SPECIFICITY OF PURIFIED FAD-MONOOXYGENASE TOWARD MORPHINE AND COCAINE CONGENERS
- METABOLIC DISPOSITION OF 8α, 9α- AND 8β, 9β-EPOXYHEXAHYDROCANNABINOL (EHHC) IN THE MOUSE
- IN VITRO METABOLIC FORMATION OF 8α, 9α-EPOXYHEXAHYDROCANNABINOL AND ITS IMPLICATION IN THE PHARMACOLOGICAL ACTIVITY OF Δ^8-TETRAHYDROCANNABINOL
- MODE OF REACTIONS BETWEEN XANTHINE OXIDASE AND AROMATIC NITRO COMPOUNDS
- IN VITRO AND IN VIVO INTERACTIONS OF Δ^8-TETRAHYDROCANNABINOL AND ITS METABOLITES WITH HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME SYSTEMS OF MICE
- STUDIES ON THE MECHANISM OF N-DEMETHYLATION OF METHAMPHETAMINE WITH PURIFIED ENZYMES
- MORPHINE CONJUGATES AS PHARMACOLOGICALLY ACTIVE METABOLITES
- SELECTIVE INDUCTION OF RAT LIVER MICROSOMAL CYTOCHROME P-448 BY 3,4,5,3', 4'-PENTACHLOROBIPHENYL AND ITS EFFECT ON LIVER MICROSOMAL DRUG METABOLISM
- THE ENHANCING EFFECT ON THE PHARMACOLOGICAL ACTIVITY OF MORPHINE BY CONJUGATION AT THE 6-POSITION
- DETERMINATION OF OXYCODONE METABOLITES IN URINES AND FECES OF SEVERAL MAMMALIAN SPECIES
- A NOVEL METABOLITE OF OXYCODONE IN THE URINE OF RABBITS
- A Colorimetric Method for the Determination of Cannabinoids with Fast Blue BB Salt