Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries.

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概要

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• The vascular effects of 15-hydroperoxyeicosatetraenoic acid (15-HPETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) were investigated on isolated helical strips of canine cerebral and coronary arteries. 15-HPETE caused strong concentration-related contraction of cerebral arteries under resting tension. After contraction with prostaglandin F<SUB>2α</SUB> (PGF<SUB>2α</SUB>), 15-HPETE caused marked relaxation of coronary arteries. The effects of 15-HETE on isolated canine arteries were similar to those of 15-HPETE. The relaxation of coronary arteries caused by both 15-HPETE and 15-HETE was completely inhibited in the presence of aspirin, but not in the presence of tranylcypromine. Preincubation of coronary and cerebral arterial strips with 15-HPETE or 15-HETE resulted in suppression of the production of 6-keto-PGF<SUB>1α</SUB> from exogenously added arachidonic acid; and 15-HPETE, but not 15-HETE, enhanced the production of HETE(s) significantly. Aspirin blocked 15-HPETE induced HETE(s) production in coronary arteries. On cerebral angiography, strong contraction of intracranial arteries was observed after intracisternal injection of 15-HPETE. On the other hand, 15-HETE had little effect on intracranial arteries in vivo. The mechanism of the vascular effects of 15-HPETE and 15-HETE will be discussed.

• 公益社団法人 日本薬理学会の論文

著者

• Kawakita Seiichi

  First Department Of Internal Medicine Shiga University Of Medical Science

• NOZAKI Mitsuhiro

  Department of Biochemistry, Shiga University of Medical Science

• Takahashi Masayuki

  First Department Of Internal Medicine Shiga University Of Medical Science

• OZAKI Nobuyuki

  First Department of Internal Medicine, Shiga University of Medical Science

• SAEKI Yukikazu

  Central Research Laboratory, Shiga University of Medical Science

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