Urate Oxidase Activity and Copper Content in the Liver of Macular Mutant Mouse, a Model Animal for Human Congenital Copper Deficiency, Menkes' Kinky Hair Disease.
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概要
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The macular mouse is an X-linked recessive inherited mutant and is considered to be a model for human congenital copper deficiency, Menkes' kinky hair disease. The activity of urate oxidase, which has been believed to be a copper enzyme, and copper content in the liver of the mutant mouse were determined. The oxidase activity was maintained at normal level even though there was very low level of copper present in the liver through days 7 to 14. Copper administration increased the copper content in the liver to the normal level, but did not affect the oxidase activity.
- 財団法人 学会誌刊行センターの論文
著者
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Shimada Morimi
Department Of Pediatrics Shiga Medical College
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NOZAKI Mitsuhiro
Department of Biochemistry, Shiga University of Medical Science
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Ishida Tetsuo
Department Of Biochemistiy Shiga University Of Medical Science
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Horiike Kihachiro
Department Of Biochemistiy Shiga University Of Medical Science
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SHIMADA Morimi
Departments of Pediatrics and Biochemistr, Shiga University of Medical Science
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KOYAMA Masahiko
Departments of Pediatrics and Biochemistr, Shiga University of Medical Science
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NOZAKI Mitsuhiro
Departments of Pediatrics and Biochemistr, Shiga University of Medical Science
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HORIIKE Kihachiro
Departments of Pediatrics and Biochemistr, Shiga University of Medical Science
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