1-置換2-ピペリドン類と塩化ホスホリルとの反応(第4報) : β-ケトアミドと4級塩の相互変換
スポンサーリンク
概要
- 論文の詳細を見る
1,5-Dibenzyl-2,3,4,4a, 5,6,7,8 (or 2,3,4,5,6,7,8,8a)-octahydrocyclobuta [1,2-b : 3,4-b'] dipyridin-1-ium salt (IIIb) was converted into 1-benzyl-2-(1-benzyl-2-oxo-3-piperidyl)-3,4,5,6-tetrahydropyridinium salt (IV) by allowing it to stand for a week or so in 20% hydrochloric acid at room temperature. IV was also formed by heating 1-benzyl-3-(5-benzylaminovaleryl)-2-piperidone (IIb) hydrochloride at about 150° or by leaving it in ethanol at room temperature. IV was transformed into IIb by hydrolysis with alkali and into IIIb by treatment with phosphoryl chloride. It was clear from these results that IIb and IIIb were interconvertible via IV.
- 公益社団法人日本薬学会の論文
- 1969-08-25
著者
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赤星 三彌
Research Laboratories, Ohta Pharmaceutical Co., Ltd.,
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赤星 三彌
Research Laboratories Ohta Pharmaceutical Co. Ltd.
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久津間 輝雄
Research Laboratories Ohta Pharmaceutical Co. Ltd.:(present Address) Research Laboratories Fujirebio
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赤星 三彌
東京大学薬学部
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久津間 輝雄
東京大学薬学部
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