Synthesis in the Benzoquinolizine Group. I. Synthesis of 1,2,3,4,6,7-Hexahydro-11bH-benzo[a]quinolizines

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概要

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• Synthesis of 1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizines (IIIa and IIIb) was described. N-Phenethyl-5-bromovaleramide (IV) and 1-phenethyl-2-piperidone (VIIa) were cyclized with a mixture of phosphoryl chloride-phosphorus pentoxide and phosphoryl chloride-polyphosphoric acid, respectively, and were reduced catalytically. Thus, the hexahydro base (IIIa) was obtained. 9,10-Methylenedioxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine (IIIb) was obtained in a good yield from the cyclized product of the corresponding piperidone (VIIb) by the same method.

• 公益社団法人日本薬学会の論文
• 1960-01-25

著者

• 阿知波 一雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 赤星 三彌

  Research Laboratories, Ohta Pharmaceutical Co., Ltd.,

• 赤星 三彌

  Research Laboratories Ohta Pharmaceutical Co. Ltd.

• 赤星 三彌

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)national Institute Of Radiol

• 久津間 輝雄

  Research Laboratories Ohta Pharmaceutical Co. Ltd.:(present Address) Research Laboratories Fujirebio

• 久津間 輝雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

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