95(PB3-6) インドネシア産植物Artocarpus communis中のリポキシゲナーゼ活性阻害物質について(ポスター発表の部)

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From ancient times the dried flower of Artocarpus communis has been used as a mosquito repellent in Indonesia. We have investigated the biological activities of the alcoholic extracts of this flower and found that the extracts include some 5-lipoxygenase inhibitors. In this paper, we now report on the isolation and structural elucidation of five new lipoxygenase inhibitors from A communis. The crude extracts of the flower of this plant were separated by repeated column chromatography on HP-20 (MeOH-H_2O, gradient) and on silica gel (hexane-EtOAc). Finally, five new compounds (AC-5-1, AC-5-2, AC-3-1, AC-3-2 and AC-3-3) were isolated from the active fractions by normal phase and reverse phase HPLC. The structures of the new compounds were determined by their IR, MS, ^1H-NMR and ^<13>C-NMR spectral data. As shown in Table 1, all these compounds exhibited strong inhibitory effects on 5-lipoxygenase. In spite of high inhibitory effects (ID_<50>=5×10^<-8>M) on 5-lipoxygenase, AC-5-1 did not exhibit any effects on prostaglandin synthase at a concentration of 10^<-5>M. Details of the biological activities on these compounds will be reported elsewhere.
天然有機化合物討論会の論文
1987-07-25