The C-Terminal Determination of Polypeptide by the Selective Tritium-labeling. V. C-Terminal Cleavage of Peptide by the Action of Acetic Anhydride
スポンサーリンク
概要
- 論文の詳細を見る
During the course of further investigation of Method B, which was previously proposed for the tritiation of C-terminal proline in the peptide chain, it was revealed that the C-terminal amino acid was cleaved to some extent under the heat-treatment of peptide in AcOH-Ac_2O solution. This type of C-terminal cleavage was confirmed gas- and paper-chromatographically and further evidences were also obtained by the C-terminal assay of the reaction products. In the present study, it was also revealed that non-C-terminal histidine residue in peptide chain underwent the hydrogen-tritium exchange reaction in its imidazole ring, when the peptide containing histidine residue was heated in a mixture of acetic anhydridetritiated water or acetic anhydride-[carboxy-^3H] acetic acid in the absence of pyridine.
- 社団法人日本薬学会の論文
- 1970-05-25
著者
-
松尾 壽之
The Institute Of Physical And Chemical Research
-
辰野 高司
The Institute of Physical Chemical Research
-
辰野 高司
理化学研究所
-
松原 央
Space Sciences Laboratory, University of California
-
藤本 康雄
The Institute Of Physical And Chemical Research
-
辰野 高司
Institute of Physical and Chemical Research
-
藤本 康雄
理研
-
辰野 高司
The Institute Of Physical And Chemical Research
-
小林 裕子
The Institute of Physical and Chemical Research
-
松原 央
Space Sciences Laboratory University Of California
関連論文
- Studies on the Racemization of Amino Acids and Their Derivatives. III. The Effect of Alkyl-, Aralkyl- and Aryl-Side Chain at α-Position of Amino Acids on Their Base-Catalyzed Racemization
- Studies on the Racemization of Amino Acids and Their Derivatives. II. On the Deuterium-Hydrogen Exchange Reaction of Amino Acid Derivatives in a Medium of Deuterated Acetic Acid
- Simultaneous Determination of N- and C-Terminal Amino Acids in Polypeptides : Selective Tritiation of DNP-Peptides
- アミノ酸誘導体のラセミ化に関する研究(第4報) : 酢酸中におけるアミノ酸のラセミ化速度と構造の関連について
- Synthesis of D-Alanine under the Asymmetric Induction due to Molecular Asymmetry
- The C-Terminal Determination of Polypeptide by the Selective Tritium-labeling. V. C-Terminal Cleavage of Peptide by the Action of Acetic Anhydride
- Recherches Enzymatiques du Metabolisme du Penicillium islandicum SOPP. I. Preliminaire de la voie Metabolique Principale de P. islandicum.
- Studies on the Metabolites of Penicillium diversum var. aureum. I
- Studies on the Biological Activities of Islandic Acid and Related Compounds
- Studies on the Constituents of Artemisia argyi LEVL et VANT
- 22 Penicillium diversum var aureumの生産する抗腫瘍性代謝産物について
- 紅足蒿(Artemisia rubripes NAKAI)の成分研究
- LEAD (IV) ACETATE-METAL HALIDE REAGENTS II. A NEW METHOD FOR THE SYNTHESIS OF β-HALO CARBOXYLATES AND β-IODO ETHERS
- 83 Penicillium islandicum Soppの生産するDNA合成阻害物質の構造
- Recherche Toxicologique des Substances Metaboliques de Penicillium carneo-lutescens
- Modification of α-Santonin. IV. Epoxidation of Germacranolide-type Sesquiterpenes
- Modification of α-Santonin. III. Synthesis of Dihydrocostunolide
- 微生物によるSantonin誘導体の構造変換
- 23 α-SantoninからGermacrane型化合物への変換 : Dihidrocostunolideの合成
- 2 Trichothecene型sesquiterpene類の全合成
- Recherches Toxicologiques sur les Substances Toxiques de Fusarium nivale : Etude Chimique des Toxins Principales, Nivalenol, Fusarenon-X et Nivalenol-4,15-di-O-acetate
- 31 麦赤カビ病菌Fusarium nivale代謝有毒成分の中毒学的検討(第6報) : Nivalenol及びその関連化合物の化学構造に関する研究
- Recherches Toxicologiques des Substances Metaboliques du Fusarium nivale. II. Effet Antileucemique du Nivalenol et du Dihydronivalenol
- Studies on Aminobutenolide Compounds. I. The Reaction of o-Phthalaldehydic Acid with Amino Compounds
- Recherches Toxicologiques sur les Substances Toxiques de Penicillium tardum. I. Isolement et Identification des Substances Cytotoxiques
- Recherches Toxicologiques des Substances Metaboliques du Fusarium nivale. VIII. La Quatrieme Substance Metabolique de F. nivale
- Recherches Toxicologiques sur les Mycotoxines qui Polluent 1e Fourrage Artificiel du Porc
- Recherches Toxicologiques des Substances Metaboliques du Fusarium nivale. VII. La Troisieme Substance Metabolique de F. nivale, le Diacetate de Nivalenol
- Nivalenol, a Toxic Principle of Fusarium nivale
- (79) 小麦の赤カビ病菌の毒株検出および毒素の本態に関する研究 : (第2報) とくに Fusarium nivale の産出する毒素抽出および病理学的所見 (菌類病(昭和43年度日本植物病理学会大会講演要旨))
- (14) コムギ赤かび病菌の毒株検出およびその毒素の研究 (昭和41年度地域部会講演要旨(夏季関東部会))
- (126) 米穀に寄生する広義赤かび病菌に関する研究 その5 : 特に動物試験 (病変米(昭和33年度 日本植物病理学会大会講演要旨))
- (8) イスランジア黄変米の研究について (昭和30年度夏季関東部会)
- 日本のマイコトキシン研究を回顧し,伝えたいこと
- 教育賞受賞 山川浩司氏の業績
- フランスの医薬分業の現状と歴史(諸外国の医薬分業の現状)
- 諸外国における薬剤師試験制度
- 「薬学教育問題について」
- 薬の歴史 : 薬学の成立とその発展(医薬品を考える)
- "個人の衛生環境によって変動する薬物活性"の問題を誰が扱うのか(衛生薬学領域における教育はいかにあるべきか)
- 慶松勝左衛門
- 共通の概念規定のもとに全薬学人が議論する習慣をもとう
- Chemical Studies on Chlorine-containing Peptide-One of the Toxic Metabolites of P. islandicum Sopp. I. Structure and Synthesis of Dehydrochlorinated-Peptide Amide
- STRUCTURES OF SECOJESACONITINE AND SUBDESCULINE, TWO NEW DITERPENOID ALKALOIDS FROM ___- ___- THUNB.
- 66(PA2-6) 高度に酸化されたα-ピロン誘導体の合成と抗腫瘍活性 : Islandic Acid I Methyl Ester,RosellisinおよびRosellisin Aldehydeの全合成(ポスター発表の部)
- フザリウム産出毒素のカブレ
- 5-Lipoxygenase Inhibitors Isolated from Gardeniae Fructus
- STRUCTURE-ACTIVITY CONSIDERATION OF NOVEL ANTICANCER PLATINUM PYRIMIDINE "GREENS"(Communications to the Editor)
- 3-CAFFEOYL-4-SINAPOYLQUINIC ACID, A NOVEL LIPOXYGENASE INHIBITOR FROM GARDENIAE FRUCTUS(Communication to the Editor)
- ISOLATION AND STRUCTURAL ELUCIDATION OF A NEW LIPOXYGENASE INHIBITOR FROM GARDENIAE FRUCTUS
- AN EFFICIENT AND STEREOCONTROLLED SYNTHESIS OF A CIS-AND TRANS-FUSED BICYCLO [5.4.0] UNDECANE RING SYSTEM VIA INTRAMOLECULAR [2+2] PHOTOCYCLOADDITION
- 95(PB3-6) インドネシア産植物Artocarpus communis中のリポキシゲナーゼ活性阻害物質について(ポスター発表の部)
- A new Cytotoxic Chlorine-Containing Polyacetylene from the Callus of Panax ginseng
- Studies on the Metabolites of Penicillium diversum var. aureum. II. : Synthesis and Cytotoxic Activity of Trihydroxytetralones
- (96) カンキツ黒点病ならびに軸腐病の発病機構に関する研究(30) : カンキツ果皮から単離された抗菌性物質について (昭和62年度日本植物病理学会大会講演要旨)