アミノ酸誘導体のラセミ化に関する研究(第4報) : 酢酸中におけるアミノ酸のラセミ化速度と構造の関連について
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概要
- 論文の詳細を見る
In relation to the racemization reaction of α-amino acid in nonaqueous acetic acid, the rate constants for the racemization of five neutral amino acids [Chemical formula] were kinetically investigated in glacial acetic acid and compared. Susceptibility of the tested amino acids to the acetic acid-induced racemization was found to decrease in the order of Ala>Leu>Phe>But>Val. This order, except Phe, was similar to the tendency observed in usual base-catalyzed racemization. The present results, combined with those reported in previous papers, ^<1,5)>suggest that acetate anion probably played a base-catalyst role in the present racemization reaction. In the case of Phe, however, another factor such as phenonium ion participation may be involved.
- 社団法人日本薬学会の論文
- 1970-09-25
著者
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松尾 壽之
The Institute Of Physical And Chemical Research
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佐藤 要
The Institute of Physical and Chemical Research
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佐藤 要
理化学研究所
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辰野 高司
理化学研究所
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松尾 壽之
理化学研究所
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辰野 高司
Institute of Physical and Chemical Research
関連論文
- Studies on the Racemization of Amino Acids and Their Derivatives. III. The Effect of Alkyl-, Aralkyl- and Aryl-Side Chain at α-Position of Amino Acids on Their Base-Catalyzed Racemization
- Studies on the Racemization of Amino Acids and Their Derivatives. II. On the Deuterium-Hydrogen Exchange Reaction of Amino Acid Derivatives in a Medium of Deuterated Acetic Acid
- Simultaneous Determination of N- and C-Terminal Amino Acids in Polypeptides : Selective Tritiation of DNP-Peptides
- Studies on the Racemization of Amino Acids and their Derivatives. I. On the Deuterium-Hydrogen Exchange Reaction of Amino Acids Derivatives in Basic Media
- アミノ酸誘導体のラセミ化に関する研究(第4報) : 酢酸中におけるアミノ酸のラセミ化速度と構造の関連について
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- The C-Terminal Determination of Polypeptide by the Selective Tritium-labeling. V. C-Terminal Cleavage of Peptide by the Action of Acetic Anhydride
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