STRUCTURE-ACTIVITY CONSIDERATION OF NOVEL ANTICANCER PLATINUM PYRIMIDINE "GREENS"(Communications to the Editor)
スポンサーリンク
概要
- 論文の詳細を見る
Platinum pyrimidine greens are very effective against L1210 cells, but the blues are inactive. A clear relationship between the activity and size of Pt-green molecules has been observed; smaller molecules with up to Pt-decanuclear complexes are much more active than larger ones. Formation of macrocells by the greens have been found for the first time with L1210 cells. The more active the green complex is, the denser is the population of the macrocells. These findings could be related to the membrane permeability.
- 公益社団法人日本薬学会の論文
- 1987-12-25
著者
-
藤本 康雄
The Institute of Physical and Chemical Research (Rikagaku Kenkyusho) Komagome, Tokyo
-
藤本 康雄
The Institute Of Physical And Chemical Research
-
藤本 康雄
College Of Pharmacy Nihon University
-
志村 武彦
National Chemical Laboratory for Industry (NCLI)
-
友廣 岳則
National Chemical Laboratory for Industry (NCLI)
-
奥野 洋明
National Chemical Laboratory for Industry (NCLI)
-
志村 武彦
National Chemical Laboratory For Industry (ncli) Tsukuba
-
丸野 清
The Institute of Physical and Chemical Research Yohmei Okuno
関連論文
- Simultaneous Determination of N- and C-Terminal Amino Acids in Polypeptides : Selective Tritiation of DNP-Peptides
- The C-Terminal Determination of Polypeptide by the Selective Tritium-labeling. V. C-Terminal Cleavage of Peptide by the Action of Acetic Anhydride
- Studies on the Metabolites of Penicillium diversum var. aureum. I
- Studies on the Biological Activities of Islandic Acid and Related Compounds
- Studies on the Constituents of Artemisia argyi LEVL et VANT
- 22 Penicillium diversum var aureumの生産する抗腫瘍性代謝産物について
- 紅足蒿(Artemisia rubripes NAKAI)の成分研究
- LEAD (IV) ACETATE-METAL HALIDE REAGENTS II. A NEW METHOD FOR THE SYNTHESIS OF β-HALO CARBOXYLATES AND β-IODO ETHERS
- 83 Penicillium islandicum Soppの生産するDNA合成阻害物質の構造
- Recherche Toxicologique des Substances Metaboliques de Penicillium carneo-lutescens
- Modification of α-Santonin. IV. Epoxidation of Germacranolide-type Sesquiterpenes
- Modification of α-Santonin. III. Synthesis of Dihydrocostunolide
- 微生物によるSantonin誘導体の構造変換
- 23 α-SantoninからGermacrane型化合物への変換 : Dihidrocostunolideの合成
- 2 Trichothecene型sesquiterpene類の全合成
- Recherches Toxicologiques sur les Substances Toxiques de Fusarium nivale : Etude Chimique des Toxins Principales, Nivalenol, Fusarenon-X et Nivalenol-4,15-di-O-acetate
- 31 麦赤カビ病菌Fusarium nivale代謝有毒成分の中毒学的検討(第6報) : Nivalenol及びその関連化合物の化学構造に関する研究
- Recherches Toxicologiques des Substances Metaboliques du Fusarium nivale. II. Effet Antileucemique du Nivalenol et du Dihydronivalenol
- Studies on the Constituents of Turkish Plants. I. Flavonol Triglycosides from the Fruit of Rhamnus thymifolius
- SELECTIVE SYNTHESIS OF NOVEL ANTICANCER PLATINUM PYRIMIDINE GREENS BY HYDROGEN PEROXIDE OXIDATION
- STRUCTURES OF SECOJESACONITINE AND SUBDESCULINE, TWO NEW DITERPENOID ALKALOIDS FROM ___- ___- THUNB.
- 66(PA2-6) 高度に酸化されたα-ピロン誘導体の合成と抗腫瘍活性 : Islandic Acid I Methyl Ester,RosellisinおよびRosellisin Aldehydeの全合成(ポスター発表の部)
- Inhibition of Deoxyribonucleic Acid Synthesis in Vitro by Anticancer Platibum Pyrimidine Greens against Daude Cells
- Modification of α-Santonin. I. An Abnormal Chlorination of 3-Hydroxy-4,5-epoxy-6,11βH-eudesm-1-en-6,12-olide with Methanesulfonyl Chloride
- PHOTOCHEMICAL SYNTHESIS OF ANTITUMOR PLATINUM PYRIMIDINE GREENS ; POSSIBLE CONTRIBUTION OF SINGLET OXYGEN(Communications to the Editor)
- CYTOTOXIC ACETYLENES FROM PANAX QUINQUEFOLIUM
- NEW FLAVONES FROM ARTOCARPUS COMMUNIS FORST.
- Inhibitory Effects of a Novel Water-Soluble Cyclophane on the Hydrolysis Reactions of Aromatic Esters
- 5-Lipoxygenase Inhibitors Isolated from Gardeniae Fructus
- STRUCTURE-ACTIVITY CONSIDERATION OF NOVEL ANTICANCER PLATINUM PYRIMIDINE "GREENS"(Communications to the Editor)
- 3-CAFFEOYL-4-SINAPOYLQUINIC ACID, A NOVEL LIPOXYGENASE INHIBITOR FROM GARDENIAE FRUCTUS(Communication to the Editor)
- ISOLATION AND STRUCTURAL ELUCIDATION OF A NEW LIPOXYGENASE INHIBITOR FROM GARDENIAE FRUCTUS
- AN EFFICIENT AND STEREOCONTROLLED SYNTHESIS OF A CIS-AND TRANS-FUSED BICYCLO [5.4.0] UNDECANE RING SYSTEM VIA INTRAMOLECULAR [2+2] PHOTOCYCLOADDITION
- A NEW APPROACH TO THE SYNTHESIS OF A BICYCLO [5. 3.0] DECANE SYSTEM FROM 7-ACETOXYTRICYCLO [5. 3. 0. 0^] DECAN-2-ONES THROUGH RETRO- AND RE-ALDOLIZATION FOLLOWED BY GROB FRAGMENTATION
- A110 ニカメイガの合成性フェロモンおよび類縁化合物の生物活性(性フェロモン3)
- 95(PB3-6) インドネシア産植物Artocarpus communis中のリポキシゲナーゼ活性阻害物質について(ポスター発表の部)
- A new Cytotoxic Chlorine-Containing Polyacetylene from the Callus of Panax ginseng
- Studies on the Metabolites of Penicillium diversum var. aureum. II. : Synthesis and Cytotoxic Activity of Trihydroxytetralones
- 副作用のないシスプラチンの開発 (化学でがんに挑む)
- 抗癌性白金ピリミジングリ-ン錯体の1段階簡便合成法とin vitroにおける生理活性
- 2重縮合反応によるテトラアザ大環状化合物の合成
- 抗がん性を有する白金ピリミジングリ-ン錯体の構造活性相関についての一考察
- 光増感反応による抗がん性白金グリ-ン錯体の合成--生成過程における1重項酸素関与の可能性について
- 抗しゅよう性白金ピリミジンブル-の合成研究--高効率合成条件とゲル濾過法による精製